Figure 9.

Coevolution between snoRNAs and their targets. A. Nucleotides of box C/D snoRNAs in the complementary region were changed in coordination with its target rRNA maintaining phylogenetical conservation of rRNA methylated sites. B. Nucleotides changed in box H/ACA snoRNAs respond to specific changes in the 18S rRNA of N. crassa . The nucleotides marked by black dot represent the 2'-O-methylation. Basepairs changed are indicated by arrows.