Table 9

miRNAs involvement in immune response [11]

miRNA

Functions

Targets


miR-15a

Decreased expression in chronic lymphocytic leukaemia

Bcl-2

miR-16

Binds to UA rich elements in 3' UTR and induces TNF alpha mRNA degradation

TNFα

miR-21

Increased expression in B-cell lymphoma and chronic lymphocytic leukaemia

miR-17-5p

Inhibits monocyte proliferation, differentiation and maturation

AML-1

miR-20a

Inhibits monocyte proliferation, differentiation and maturation

AML-1

miR-106a

Inhibits monocyte proliferation, differentiation and maturation

AML-1

miR-24

Inhibits replication of vesicular stomatitis virus

miR-29a

Down-regulated in B-cell chronic lymphocytic leukemia

Tcl-1

miR-122

Required for hepatitis C proliferation in liver

miR-125b

Expression downregulated by LPS and oscillations in expression after exposure to TNF alpha

TNFα

miR-146a

Expression induced in macropahges and epithilial following activation of TLR or exposure to TNF alpha and IL-1beta

IRAK1, TRAF6

miR-146b

LPS induced expression induced in macrophages

IRAK1, TRAF6

let-7i

Regulates TLR-4 and contributes to cholangiocyte immune responses

miR-181a

Positive regulator of B-cell development and CD4+ T-cell selection, activation and sensitivity

SHP-2, PTPN22, DUSP5, DUSP6


Wang et al. BMC Genomics 2009 10:512   doi:10.1186/1471-2164-10-512

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