Common structural elements of nuclear receptors. The variable A/B region contains a transcriptional activation function (AF-1) as well as regions that are targets for post-translational modification and interact with other cofactors. The highly conserved C region or DNA-binding domain (DBD) contains two typical cysteine-rich zinc finger motifs. The D region links the DBD and the ligand-binding domain (LBD). The E region contains the LBD. This domain is involved in dimerization, contains the ligand --binding pocket, modulates positively or negatively transcription activity, and has an activation function helix (AF-2) for ligand dependent transactivation. The F region represents the COOH terminal end of the receptor.
Thomson et al. BMC Genomics 2009 10:500 doi:10.1186/1471-2164-10-500