Table 3

Processed/duplicated pseudogenes

Human

Chimp

Mouse

Rat

Chicken

Zebrafish

Pufferfish

Fruitfly

Worm


HK

1/0 [4]

1/2

0/1 [3]

- [3]

0/2

-

-

-

-

GPI

- [1]

-

1/0 [1]

- [1]

-

-

-

-

-

PFK

- [3]

-

- [3]

- [3]

-

0/1

-

-

-

ALDO

1/1 [3]

1/1

11/0 [2]

7/0 [3]

0/1

-

-

-

-

TPI

3/0 [1]

2/1

6/1 [1]

3/1 [1]

-

-

-

-

-

GAPDH

60/2 [2]

47/3

285/46 [2]

329/35 [2]

0/1

-

-

-

-

PGK

1/1 [2]

1/2

2/0 [2]

12/0 [1]

-

-

-

-

-

PGM

12/0 [2]

13/1

9/0 [2]

3/0 [2]

-

-

-

-

-

ENO

1/0 [3]

1/2

12/1 [3]

36/3 [3]

-

-

-

-

-

PK

2/0 [2]

3/0

10/3 [2]

4/1 [1]

-

-

-

-

-

LDH

10/2 [3]

9/1

27/7 [3]

25/4 [3]

-

-

-

-

-


Total

97

91

422

463

4

1

0

0

0


Numbers of pseudgenes (processed/duplicated) and [known parent gene isozymes] for each glycolytic enzyme. The numbers of known parent gene isozymes are shown only for human, mouse, and rat because they constitute the most completely annotated genomes in ENSEMBL. A dash '-' indicates that there are no processed or duplicated pseudogenes derived from a particular enzyme in a particular vertebrate genome. The chicken, zebrafish, pufferfish, fruitfly, and worm genomes contain very few or no pseudogenes, the human and chimpanzee genomes a moderate number, and the mouse and rat genomes significantly more. The pseudogene copy number for GAPDH far outnumbers those of any other glycolytic enzyme. Abbreviations: HK, hexokinase; GPI, glucose-6-phosphate isomerase; PFK, 6-phosphofructokinase; ALDO, aldolase; TPI, triose-phosphate isomerase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; ENO, enolase; PK, pyruvate kinase; LDH, lactate dehydrogenase.

Liu et al. BMC Genomics 2009 10:480   doi:10.1186/1471-2164-10-480

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