Table 1

Genes in HCV associated pathways identified as regulated by miRNAs during HCV infection

Canonical pathways (IPA)

Predicted target genes

Number of targets


Chemokine Signaling

SRC, CALM3, CALM2, MAPK6, PPP1CB, KRAS, LIMK2, PTK2, CAMK2D, RRAS2, MAPK14, CCL2, RHOA, CXCL12, CALM1, PRKCB

16


B Cell Receptor Signaling

MAP2K4, MAP3K14, CALM3, PIK3R1, CALM2, MAPK6, KRAS, INPPL1, PTEN, BCL2L1, CAMK2D, RRAS2, MAPK14, BCL10, PAG1, LYN, PIK3AP1, CALM1, PRKCB

19


PTEN Signaling

PIK3R1, MAPK6, INPPL1, KRAS, CCND1, PTEN, PTK2, BCL2L1, RRAS2, GHR, BMPR1A, CDKN1A, FASLG

13


IL-6 Signaling

MAP2K4, IL6ST, MAP3K14, MAPK6, MAP4K4, KRAS, IL1R1, STAT3, COL1A1, IL1F9, RRAS2, MAPK14, MAPKAPK2

13


ERK/MAPK Signaling

RAP1B, SRC, PIK3R1, MAPK6, PPP1CB, KRAS, STAT3, PPP2R5A, DUSP2, EIF4E, PLA2G4C, YWHAQ, PTK2, MAPKSP1, RRAS2, ELF3, PRKCB, PRKAR1A

18


JAK/Stat Signaling

RRAS2, PIK3R1, CDKN1A, SOCS6, MAPK6, KRAS, STAT3

7


Peng et al. BMC Genomics 2009 10:373   doi:10.1186/1471-2164-10-373

Open Data