Estimated false detection rates associated with different thresholds for miRNA-mRNA expression correlations. The x-axis is a series of thresholds for the Pearson correlation coefficient. The requirement of P < 0.01 was applied for all thresholds at the same time. The y-axis has false detection rates for the corresponding thresholds. The dotted lines indicate that the estimated false detection rate is ~5.7% when the threshold is chosen as Pearson correlation coefficient r < = -0.56 and P < 0.01. For selected thresholds, the numbers aside show the total number of miRNA-mRNA pairs satisfying the corresponding threshold and the estimated false detection rate. The requirement of P < 0.01 alone has estimated false detection rate as ~14% in this dataset.
Peng et al. BMC Genomics 2009 10:373 doi:10.1186/1471-2164-10-373