Histograms of all correlation coefficients for each gene product obtained from each of the three comparisons, and one showing those of randomly picked Ensembl ID pairs. Figures 3a – 3c show the RNA oligo versus protein profiles, RNA cDNA versus protein profiles, and the RNA oligo versus RNA cDNA profiles, which yielded mean correlation coefficients of 0.25, 0.20 and 0.52, respectively. The distributions of correlation coefficients between RNA values obtained using both RNA platforms and the protein values have Gaussian shapes, but with some bimodal characteristics, in which most of the data points are centered at the respective mean, but shoulders can be seen at correlation coefficients of ~0.5 – 0.7. For the RNA assay correlations the distributions follow a beta distribution. The randomly picked pairs have a mean value close to zero, indicating that there is no apparent bias in the data set.
Gry et al. BMC Genomics 2009 10:365 doi:10.1186/1471-2164-10-365