Features of CNV dataset. (A) 99 CNV genes (58 amplifications, 41 deletions) were detected in a single isolate whereas 87 were replicated between isolates and classed as common CNVs. (B) Consecutively detected CNV genes are infrequent for both amplifications (black bars) and deletions (white bars), the vast majority being non-adjacent to variable regions, the few large variants that we detected have been previously described and include sub-telomeric truncations in chromosomes 2 and 9 and amplification of the pfmdr1 gene locus on chromosome 5. Within consecutive CNV regions it was rare to find hybridisation signals uniformly outside of the cut-offs. Genes that precluded detection using this stringent cut-off though showed clear patterns of variation were identified as those adjacent to identified CNV genes and possessed a log2 ratio of +/- 0.8. (C) Length of CNV genes was shown to be a highly significant property of CNV genes being smaller than non-CNV genes.
Cheeseman et al. BMC Genomics 2009 10:353 doi:10.1186/1471-2164-10-353