Table 1

Biological processes identified by PANTHER [23] as being significantly over-represented (p < 0.05) in the 157-transcript sex-specific SAM-list compared to the NCBI human reference gene list.

Biological process

Detected number of genes in SAM list

Expected number of genes based on NCBI reference list

p-value


Extracellular matrix protein-mediated signaling

4

0.29

0.000239

Cell adhesion-mediated signaling

8

1.8

0.000493

Cell communication

15

5.77

0.000674

Chromatin packaging and remodeling

6

1.13

0.00101

Cell cycle

13

4.8

0.00108

Mitosis

7

1.82

0.00246

Chromosome segregation

4

0.58

0.0028

Cell adhesion

9

2.96

0.00303

Embryogenesis

4

0.67

0.0048

Cell structure

9

3.27

0.00575

Gametogenesis

5

1.15

0.00614

Cell structure and motility

12

5.46

0.00878

Blood clotting

3

0.44

0.00993

Developmental processes

18

10.24

0.0134

Stress response

4

0.95

0.0157

mRNA transcription

3

9.11

0.0166

Receptor protein tyrosine kinase signaling pathway

4

1

0.0187

Protein modification

11

5.5

0.0225

Cell proliferation and differentiation

10

4.89

0.0253

DNA metabolism

5

1.71

0.0294

Protein metabolism and modification

22

14.46

0.0294

Signal transduction

24

16.21

0.0305

Lipid, fatty acid and steroid metabolism

8

3.66

0.0313

Protein phosphorylation

7

3.14

0.0389

Other homeostasis activities

2

0.33

0.0432

NO mediated signal transduction

1

0.05

0.0465

DNA repair

3

0.8

0.0474

Immunity and defense

11

6.27

0.05


Holterhus et al. BMC Genomics 2009 10:292   doi:10.1186/1471-2164-10-292

Open Data