Open Access Research article

Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes

Paul-Martin Holterhus1*, Jan-Hendrik Bebermeier2, Ralf Werner3, Janos Demeter4, Annette Richter-Unruh5, Gunnar Cario6, Mahesh Appari6, Reiner Siebert7, Felix Riepe6, James D Brooks8 and Olaf Hiort3

Author Affiliations

1 Department of Pediatrics, Christian Albrechts University of Kiel, Germany

2 Eppendorf Biochip Systems, Hamburg, Germany

3 Department of Pediatric and Adolescent Medicine, University of Lübeck, Lübeck, Germany

4 Department of Biochemistry, Stanford University School of Medicine, CA, USA

5 Department of Pediatrics, University of Essen, Essen, Germany

6 Department of Pediatrics, Christian Albrechts University of Kiel, Kiel, Germany

7 Institute of Human Genetics, Christian Albrechts University of Kiel, Kiel, Germany

8 Department of Urology, Stanford University School of Medicine, CA, USA

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BMC Genomics 2009, 10:292  doi:10.1186/1471-2164-10-292

Published: 1 July 2009

Additional files

Additional file 1:

Phenotypic, clinical and molecular background information on the control individuals and the DSD patients corresponding to the PBMC sample numbers as indicated in the first column.

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Additional file 2:

Text file to visualize data for Figure 1 together with additional files 3, 4 and 5 in TreeView [54].

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Additional file 3:

Zip file containing cdt file. Cluster file to visualize data for Figure 1 together with additional files 2, 4 and 5 in TreeView [54].

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Additional file 4:

Zip file containing atr file. Array tree file to visualize data for Figure 1 together with additional files 2, 3 and 5 in TreeView[54]

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Additional file 5:

Zip file containing gtr file. Gene tree file to visualize data for Figure 1 together with additional files 2, 3 and 4 in TreeView [54].

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Additional file 6:

Text file to visualize data for Figure 3 together with additional files 7, 8 and 9 in TreeView [54].

Format: TXT Size: 58KB Download file

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Additional file 7:

Zip file containing cdt file. Cluster file to visualize data for Figure 3 together with additional files 6, 8 and 9 in TreeView [54].

Format: ZIP Size: 24KB Download file

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Additional file 8:

Zip file containing atr file. Array tree file to visualize data for Figure 3 together with additional files 6, 7 and 9 in TreeView [54].

Format: ZIP Size: 1KB Download file

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Additional file 9:

Zip file containing a gtr file. Gene tree file to visualize data for Figure 3 together with additional files 6, 7 and 8 in TreeView [54].

Format: ZIP Size: 2KB Download file

Open Data