Research article
Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3
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* Corresponding author: Ben-Wen Li bli@wustl.edu
1 Department of internal medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
2 The Genome Sequencing Center, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA
3 J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
4 Divisions of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
BMC Genomics 2009, 10:267 doi:10.1186/1471-2164-10-267
Published: 15 June 2009Additional files
Additional file 1:
Summary of BLAST output of BmV2array elements vs. NCBI_NR. The data provided represent a similarity search of BmV2 array sequences against NCBI non-redundant database (downloaded Nov 14, 2006).
Format: XLS Size: 3.1MB Download file
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Additional file 2:
Complete RNAi information of C. elegans homologues of Brugia genes on BmV2array. The C. elegans homologues of Brugia genes on the BmV2array were found to have various RNAi phenotypes.
Format: XLS Size: 942KB Download file
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Additional file 3:
Summary of protein domain matches for BmV2array elements. The protein domain matches of BmV2array against InterProScan v13.1 database.
Format: XLS Size: 826KB Download file
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Additional file 4:
Summary of KEGG analysis of BmV2array. The top match of pathway mapping for BmV2array sequences.
Format: XLS Size: 143KB Download file
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Additional file 5:
Top 20 protein domain matches for BmV2array elements. The data provided represent top 20 protein domains matched in BmV2array sequences.
Format: DOCX Size: 13KB Download file
Additional file 6:
Up-regulated genes in the L3 type. The up-regulated genes in pair-wise comparison of L3i vs L3c and L3ir vs L3c.
Format: XLS Size: 197KB Download file
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Additional file 7:
RNAi phenotypes of C. elegans homologues in L3 the gene sets. The C. elegans homologues of Brugia genes up-regulated in L3 (L3i, L3ir and L3c) were found to have various RNAi phenotypes.
Format: XLS Size: 58KB Download file
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Additional file 8:
Complete KEGG analysis in the L3 gene set. The KEGG pathway mapped in the L3 gene set.
Format: XLS Size: 117KB Download file
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Additional file 9:
Significant protein domains in each L3 gene set. The most significant protein domains matched in each L3 gene set.
Format: XLS Size: 23KB Download file
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Additional file 10:
Significant GO terms in the L3i gene set. The statistically significant Gene Ontology terms in the L3i gene set.
Format: XLS Size: 24KB Download file
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Additional file 11:
L3i genes involved in gluconeogenesis. The genes up-regulated in L3i were involved in gluconeogenesis.
Format: XLS Size: 20KB Download file
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Additional file 12:
Significant GO terms in the L3ir gene set. The statistically significant Gene Ontology terms were mapped in the L3ir gene set.
Format: XLS Size: 19KB Download file
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Additional file 13:
Significant GO terms in the L3c gene set. The statistically significant Gene Ontology terms in the L3c gene set.
Format: XLS Size: 22KB Download file
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Additional file 14:
Up-regulated genes confirmed by qRT-PCR. Genes up-regulated by microarray were confirmed by real-time qRT-PCR.
Format: XLS Size: 22KB Download file
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Additional file 15:
Potential drug targets in each L3 gene set. The potential drug targets were identified in each L3 gene set.
Format: XLS Size: 53KB Download file
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Additional file 16:
Primers of selected genes confirmed by real-time qRT-PCR. The primers used in real-time qRT-PCR for the confirmation.
Format: XLS Size: 24KB Download file
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