Table 6

Expression levels and interindividual differences of currently known peripheral disease genes with RPE expression[26].

gene symbol

Genbank accession

mean intensity (μint) (percentile)

CV (percentile)


high interindividual variation (CV > 90th percentile)


COL9A1

NM_001851

5,628

(88)

225

(100)


RBP4

NM_006744

20,291

(97)

196

(100)


COL2A1

NM_001844

527

(37)

122

(97)


GNAT1

NM_000172

100,271

(100)

80

(92)


RDH5

NM_002905

6,716

(90)

78

(92)


RLBP1

NM_000326

43,011

(99)

74

(91)


intermediate interindividual variation (CV 10th – 90th percentile)


PRCD

AK054729

46,964

(99)

66

(88)


GUCY2D

NM_000180

2,672

(75)

64

(87)


NPHP3

AI200954

3,266

(79)

63

(86)


IMPDH1

NM_000883

12,177

(95)

63

(86)


LRAT

NM_004744

15,935

(96)

62

(86)


LRP5

NM_002335

519

(37)

62

(86)


RD3

AV721413

11,010

(95)

61

(86)


RGR

NM_002921

39,454

(99)

57

(83)


TULP1

NM_003322

6,284

(89)

57

(83)


AHI1

AL136797

7,168

(91)

56

(82)


SEMA4A

NM_022367

2,824

(76)

54

(80)


TEAD1

AL133574

4,473

(84)

51

(78)


PANK2

NM_024960

273

(20)

48

(75)


PEX7

NM_000288

1,734

(65)

48

(75)


OAT

NM_000274

3,762

(81)

45

(71)


CDH3

NM_001793

9,589

(93)

45

(71)


BBS10

NM_024685

1,556

(63)

45

(71)


PRPF8

NM_006445

6,510

(90)

40

(64)


TIMM8A

NM_004085

913

(50)

39

(63)


FZD4

NM_012193

7,964

(92)

39

(62)


OPA3

NM_025136

20,540

(97)

39

(62)


COL11A1

NM_001854

911

(50)

38

(61)


PGK1

NM_000291

12,114

(95)

37

(59)


CYP4V2

AK022114

5,411

(87)

37

(58)


JAG1

NM_000214

1,394

(60)

35

(53)


MYO7A

NM_000260

6,691

(90)

34

(53)


BBS2

NM_031885

4,446

(84)

34

(51)


PAX2

NM_003990

2,946

(77)

33

(50)


BBS1

NM_024649

3,750

(81)

32

(46)


NYX

NM_022567

372

(28)

32

(45)


ABCC6

NM_001171

1,555

(63)

28

(35)


MERTK

NM_006343

4,763

(85)

28

(35)


ARL6

BI914103

1,023

(53)

28

(34)


MFRP

NM_031433

13,200

(96)

27

(33)


PXMP3

NM_000318

5,341

(87)

25

(25)


ALMS1

AB002326

962

(51)

23

(20)


MKKS

NM_018848

2,056

(69)

22

(16)


NDP

NM_000266

1,335

(59)

20

(14)


PHYH

NM_006214

3,293

(79)

20

(12)


WFS1

NM_006005

4,935

(86)

19

(10)


low interindividual variation (CV < 10th percentile)


PRPF31

NM_015629

3,187

(78)

17

(06)


PEX1

NM_000466

3,008

(77)

15

(04)


PRPF3

NM_004698

7,057

(91)

14

(03)


TRIM32

NM_012210

2,277

(71)

13

(02)


CLN3

NM_000086

2,330

(72)

8

(0)


Data are grouped by coefficient of variation (CV) in descending order into three groups, high CV (> 90th percentile, CV > 72), an intermediate group (CV 10th – 90th percentile) and CV low (< 10th percentile, CV < 19).

Booij et al. BMC Genomics 2009 10:164   doi:10.1186/1471-2164-10-164

Open Data