Table 3

The top thirty genes with the highest interindividual variation in expression levels (CV) between six healthy human donors, sorted descending by coefficient of variation (CV).

gene symbol

Genbank ID

mean intensity μint perc

CV perc

gene name


HSD17B2

NM_002153

95

99

Hydroxysteroid (17-beta) dehydrogenase 2


MYOC

NM_000261

99

99

Myocilin, trabecular meshwork inducible glucocorticoid response


OGN

NM_014057

92

99

Osteoglycin (osteoinductive factor, mimecan)


SFRP4

NM_003014

93

99

Secreted frizzled-related protein 4


AOC2

NM_009590

91

99

Amine oxidase, copper containing 2 (retina-specific)


DIO3

NM_001362

85

99

Deiodinase, iodothyronine, type III


SLC2A5

NM_003039

62

99

Solute carrier family 2 (facilitated glucose/fructose transporter), member 5


XIST

AK025198

99

99

X (inactive)-specific transcript


TFPI2

NM_006528

99

99

Tissue factor pathway inhibitor 2


CYR61

NM_001554

98

99

Cysteine-rich, angiogenic inducer, 61


FGFBP2

NM_031950

84

99

Ksp37 protein


FBP2

NM_003837

64

99

Fructose-1,6-bisphosphatase 2


EGFL6

NM_015507

74

99

EGF-like-domain, multiple 6


IL8

NM_000584

66

99

Interleukin 8


MFAP4

L38486

99

99

Microfibrillar-associated protein 4


CCL2

NM_002982

90

99

Chemokine (C-C motif) ligand 2


ZIC1

NM_003412

67

99

Zinc family member 1 (odd-paired homolog, Drosophila)


COL9A1

NM_001851

88

99

Collagen, type IX, alpha 1


CCL26

NM_006072

79

99

Chemokine (C-C motif) ligand 26


PITX2

NM_000325

89

99

Paired-like homeodomain transcription factor 2


ALDH1A1

NM_000689

78

99

Aldehyde dehydrogenase 1 family, member A1


HBG1

NM_000559

75

99

Hemoglobin, gamma A


S100A6

NM_014624

99

99

S100 calcium binding protein A6


IL6

NM_000600

77

99

Interleukin 6 (interferon, beta 2)


HBG2

NM_000184

71

99

Hemoglobin, gamma G


C13orf33

NM_032849

93

99

Chromosome 13 open reading frame 33


RBM3

NM_006743

96

99

RNA binding motif (RNP1, RRM) protein 3


CFB

NM_001710

94

99

Complement factor B


EGR1

NM_001964

99

99

Early growth response 1


PTX3

NM_002852

97

99

Pentraxin-related gene, rapidly induced by IL-1 beta


Note that although XIST, EGFL6 and RBM3 are x-chromosomal transcripts, their high interindividual variation could not be explained by the gender of the donors (data not shown). Perc: percentile.

Booij et al. BMC Genomics 2009 10:164   doi:10.1186/1471-2164-10-164

Open Data