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Open Access Highly Accessed Research article

Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis

Tao Cui1, Lei Zhang1, Xizhou Wang12 and Zheng-Guo He1*

Author Affiliations

1 National Key Laboratory of Agricultural Microbiology, Center for Proteomics Research, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China

2 Department of Medicine, Lishui University, Lishui 323000, PR China

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BMC Genomics 2009, 10:118  doi:10.1186/1471-2164-10-118

Published: 19 March 2009

Additional files

Additional file 1:

A protein-protein interaction network of M. tuberculosis H37Rv. The data provided represent the protein interaction network of M. tuberculosis H37Rv generated from HPM method which composed with 793 individual proteins and 6091 interaction pairs.

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Additional file 2:

Top 20 highly connected Nodes in the network. The data provided represent the top 20 highly connected Nodes in the network.

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Additional file 3:

Hypothetical proteins in the network. The data present the hypothetical proteins in the network.

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Additional file 4:

Top 10 hits compounds in structure based virtual screen. The data provided top 10 hits compounds in structure based virtual screen.

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Additional file 5:

The interactome of Mycobacterium tuberculosis obtained based on the experimentally verified interactions from DIP. The data present all protein-protein interactions of Mycobacterium tuberculosis obtained based on the experimentally verified interactions from DIP.

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Additional file 6:

Identity, coverage and E-value of each query protein of Mycobacterium tuberculosis to the hit protein in DIP. The data described the identity, coverage and E-value of each query protein of Mycobacterium tuberculosis to the hit protein in DIP.

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Additional file 7:

Primers and plasmids used in the study. The data present the primers and plasmids used in the study.

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