Table 2

TDR and FDR under Model 2

RF
 MARS
Approach
 TDR
 FDR
 TDR
 FDR
1. Include Z
 +
 -
 +
 +
2. Stratify by Z
 -
 +
 -
 +
3. Residualize by Z
 -
 +
 +
 +
4. Ignore Z
 +
 -
 +
 -

Correlation between X1 and Z is varied as shown in Figures 3 and 4: "+" indicates reasonable TDR (> 80 for RF and > 70% for MARS) or low FDR (< 20% for RF and < 10% for MARS) for all levels of correlation; and "-" indicates decreasing TDR or increasing FDR as correlation increases.

Nonyane and Foulkes BMC Genetics 2008 9:71   doi:10.1186/1471-2156-9-71