Research article
Population substructure in Finland and Sweden revealed by the use of spatial coordinates and a small number of unlinked autosomal SNPs
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* Corresponding author: Ulf Hannelius ulf.hannelius@ki.se
1 Department of Biosciences and Nutrition, Karolinska Institutet, 14157 Huddinge, Sweden
2 Department of Medical Genetics, University of Helsinki, Helsinki, Finland
3 Finnish Genome Center, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
4 Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Norway
5 Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
6 Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden
7 Clinical Research Centre, Karolinska University Hospital, Stockholm, Sweden
BMC Genetics 2008, 9:54 doi:10.1186/1471-2156-9-54
Published: 19 August 2008Additional files
Additional file 1:
The number of samples from each county and region in Finland and Sweden. The sample sizes both before and after quality control are given for both the SNP and the STR analysis.
Format: XLS Size: 43KB Download file
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Additional file 2:
SNP marker information and allele frequencies for data from pooled Swedes and Finns, Swedes, Finns, and HapMap populations. The reference alleles for the frequency calculations are based on the minor allele frequencies in the pooled Finnish and Swedish data.
Format: XLS Size: 39KB Download file
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Additional file 3:
Summary information of the STR data set of the Finnish samples. The HWE p-values are based on 10,000 permutations of the observed alleles into genotypes.
Format: XLS Size: 37KB Download file
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Additional file 4:
SNP genotyping error estimates based on replicate genotypes from 356 Swedish and 89 Finnish samples. The whole genome amplification error rate was estimated by genotyping a set of 89 Swedish samples that had been whole genome amplified in two independent WGA reactions. Hardy-Weinberg equilibrium p-values are based on a standard χ2-test.
Format: XLS Size: 41KB Download file
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Additional file 5:
The results of chi-square tests for the distribution of allele frequencies of SNP markers between the Finnish and Swedish counties and regions. The p-values are based on 100,000 permutations. Those with a nominal significance below 0.01 are bolded, with their numbers and the false discovery rate (FDR) summarized below.
Format: XLS Size: 38KB Download file
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Additional file 6:
The results of chi-square tests for the distribution of allele frequencies of STR markers between the Finnish counties and regions. The p-values are based on 100,000 permutations. Those with a nominal significance below 0.01 are bolded, with their numbers and the false discovery rate (FDR) summarized below.
Format: XLS Size: 36KB Download file
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Additional file 7:
Number of individuals with foreign background (born abroad or both parents born abroad) in Sweden in 2003, stratified by county and region.
Format: XLS Size: 37KB Download file
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