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SNP haplotypes in COMT gene |
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| aHaplotype |
DM (393) n*;f** |
CRI (372) n*;f** |
χ2 |
P |
OR (95% CI) |
|
|
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| 1111 |
50 (0.127) |
64 (0.172) |
3.18 |
0.074 |
1.44 (0.96–2.15) |
| 1112 |
33 (0.084) |
04 (0.01) |
20.48 |
b< 0.001 |
0.12 (0.04–0.34) |
| 1121 |
59 (0.150) |
50 (0.134) |
0.33 |
0.56 |
0.89 (0.59–1.33) |
| 1122 |
03 (0.007) |
28 (0.075) |
22.69 |
b < 0.001 |
10.66 (3.21–35.38) |
| 1211 |
39 (0.01) |
43 (0.115) |
0.08 |
0.78 |
1.07 (0.67–1.68) |
| 1212 |
55 (0.14) |
51 (0.137) |
0.005 |
0.94 |
0.98 (0.65–1.48) |
| 1221 |
06 (0.015) |
02 (0.005) |
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| 2111 |
23 (0.058) |
24 (0.064) |
0.138 |
0.71 |
1.12 (0.62–2.02) |
| 2112 |
00 (0.00) |
04 (0.01) |
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| 2121 |
103 (0.262) |
62 (0.166) |
9.927 |
b0.0016 |
0.57 (0.40–0.81) |
| 2122 |
13 (0.033) |
20 (0.05) |
2.04 |
0.15 |
1.67 (0.82–3.41) |
| 2211 |
01 (0.002) |
08 (0.021) |
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| 2212 |
06 (0.015) |
05 (0.013) |
0.04 |
0.84 |
0.89 (0.27–2.92) |
| 2221 |
02 (0.005) |
07 (0.019) |
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aOrder of SNPs in the COMT haplotypes: -287 A>G, 408 C>G, 472 G > A and 900 Ins/Del C bSignificant after Bonferroni's correction α = 0.0035 *n = total number **f = frequency | |||||
Prasad et al. BMC Genetics 2008 9:26 doi:10.1186/1471-2156-9-26 |
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