Open Access Highly Accessed Research article

Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping

Adam B Olshen1, Bert Gold6, Kirk E Lohmueller8, Jeffery P Struewing7, Jaya Satagopan1, Stefan A Stefanov6, Eleazar Eskin9, Tomas Kirchhoff3, James A Lautenberger6, Robert J Klein4, Eitan Friedman10, Larry Norton3, Nathan A Ellis11, Agnes Viale5, Catherine S Lee2, Patrick I Borgen2, Andrew G Clark8, Kenneth Offit3 and Jeff Boyd2,3*

1 Departments of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

2 Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

3 Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

4 Programs in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

5 Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

6 Laboratories of Genomic Diversity, National Cancer Institute, Bethesda, MD, USA

7 Population Genetics, National Cancer Institute, Bethesda, MD, USA

8 Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA

9 Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA

10 Chaim Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

11 Department of Medicine, University of Chicago, Chicago, IL, USA

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BMC Genetics 2008, 9:14 doi:10.1186/1471-2156-9-14

Published: 5 February 2008

Additional files

Additional File 1:

Table S1. Distribution of SNPs on each chromosome arm

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Additional File 2:

Figure S1.Percentage of No Calls per SNP by array type

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Additional File 3:

Figure S2. Percentage of No Calls per SNP by array type for SNPS with completion rate of greater than 99.6%

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Additional File 4:

Figure S3. Percentage of No Calls per SNP by array type in CEU

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Additional File 5:

Figure S4. Percentage of No Calls per SNP by array type in CEU

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Additional File 6:

Figure S5. Analysis of Hardy-Weinberg Departures

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Additional File 7:

Figure S6. A sliding window plot of average r2 values across chromosome 22. For this analysis, 1.7 Mb windows with a 1.6 Mb overlap were utilized.

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Additional File 8:

Figure S7. The proportion of SNPs with D' = 1 as a function of distance between SNPs, with data drawn from chromosome 1.

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