Table 4

Allele frequencies of the polymorphisms associated with melanogenesis, Hirschsprung disease, AMD, and the ability to taste PTC.

Melanogenesis

Hirschsprung

AMD

Ability to Taste PTC

Gene Name:

SLC24A5

RET

CFH

LOC387715

TAS2R38

TAS2R38

TAS2R38

Nucleotide Change:

g.13242G>A

g.9349G>A

g.37989T>C

g.205G>T

g.144G>C

g.784C>T

g.885A>G


n

G

T

C

T

C

C

G


Mother Tongue

Assamese

26

0.260

0.240

0.360

0.200

0.340

0.360

0.360

Bengali

27

0.293

0.207

0.276

0.397

0.310

0.310

0.310

Gujarati

181

0.208

0.271

0.333

0.375

0.313

0.313

0.313

Hindi

29

0.105

0.209

0.267

0.244

0.349

0.360

0.360

Kannada

24

0.268

0.232

0.304

0.464

0.196

0.250

0.250

Kashmiri

24

0.020

0.100

0.260

0.340

0.480

0.500

0.500

Konkani

43

0.058

0.250

0.385

0.269

0.308

0.308

0.308

Malayalam

25

0.259

0.259

0.222

0.500

0.259

0.296

0.296

Marathi

26

0.296

0.259

0.278

0.204

0.407

0.407

0.426

Marwari

25

0.041

0.273

0.265

0.334

0.384

0.398

0.406

Oriya

27

0.154

0.346

0.212

0.250

0.346

0.365

0.365

Parsi

25

0.100

0.300

0.300

0.380

0.280

0.280

0.300

Punjabi

28

0.052

0.293

0.431

0.414

0.328

0.310

0.328

Tamil

29

0.036

0.179

0.250

0.393

0.339

0.321

0.375

Telugu

28

0.000

0.188

0.167

0.354

0.417

0.417

0.417

FST

0

0.011

0.009

0

0.009

0.010

0.011

p-value

1

1

1

1

1

1

1


Gender

Female

237

0.110

0.232

0.268

0.348

0.331

0.338

0.342

Male

339

0.117

0.261

0.289

0.330

0.363

0.376

0.386

FST

0.049

0.020

0.037

0.042

0.020

0.007

0

p-value

0.825

0.887

0.847

0.837

0.887

0.933

1


Population

Cohort

576

0.114

0.249

0.280

0.338

0.350

0.360

0.368

Standard Error

0.028

0.015

0.018

0.024

0.018

0.017

0.017

HWE Constant

0.004

0.003

0.009

0.006

0.002

0.002

0.002

p-value

0.304

0.654

0.350

0.513

0.926

0.855

0.857

Welch modified t-test:

Africa

4.21 × 10-14

3.86 × 10-4

3.24 × 10-8

0.005

Europe

2.80 × 10-4

4.20 × 10-3

0.068

2.43 × 10-6

5.78 × 10-5

1.37 × 10-4

Asia

7.18 × 10-14

1.55 × 10-8

0.018

0.055

7.97 × 10-6

7.60 × 10-6

Americas

0.024

0.006

1.92 × 10-5

1.64 × 10-5

Oceania

0.090

0.009

0.003


P-values significant at <0.05 are shown in bold.

Pemberton et al. BMC Genetics 2008 9:13   doi:10.1186/1471-2156-9-13

Open Data