Table 2 |
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|
Allele frequencies of the polymorphisms associated with the metabolic disorders of diabetes, hypertension, and atherosclerosis. |
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|
Diabetes |
Hypertension |
Atherosclerosis |
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|
Gene Name: |
PTPN22 |
CAPN10 |
TCF7L2 |
CYP3A5 |
AGT |
GNB3 |
ALOX5 |
ALOX5 |
ALOX5 |
ALOX5 |
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|
Nucleotide Change: |
g.36677C>T |
g.4834T>C |
g.98386G>T |
g.6980G>A |
g.802C>T |
g.4423C>T |
MS (5'-GGGCGG-3' starting at -145) |
g.20C>T |
g.8322G>A |
g.50778G>A |
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|
|
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|
n |
°N |
T |
C |
T |
A |
T |
T |
3 |
4 |
5 |
6 |
7 |
8 |
T |
A |
A |
|
|
|
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|
Mother Tongue |
|||||||||||||||||
|
Assamese |
26 |
26.00 |
0.000 |
0.220 |
0.280 |
0.220 |
0.400 |
0.280 |
0.000 |
0.160 |
0.800 |
0.040 |
0.000 |
0.000 |
0.140 |
0.000 |
0.020 |
|
Bengali |
27 |
23.00 |
0.017 |
0.224 |
0.138 |
0.207 |
0.414 |
0.293 |
0.000 |
0.276 |
0.655 |
0.069 |
0.000 |
0.000 |
0.276 |
0.017 |
0.000 |
|
Gujarati |
181 |
23.00 |
0.000 |
0.167 |
0.167 |
0.313 |
0.229 |
0.396 |
0.000 |
0.167 |
0.792 |
0.042 |
0.000 |
0.000 |
0.188 |
0.000 |
0.000 |
|
Hindi |
29 |
30.30 |
0.012 |
0.209 |
0.244 |
0.221 |
0.395 |
0.279 |
0.000 |
0.186 |
0.767 |
0.047 |
0.000 |
0.000 |
0.186 |
0.012 |
0.000 |
|
Kannada |
24 |
15.00 |
0.000 |
0.268 |
0.214 |
0.339 |
0.339 |
0.411 |
0.000 |
0.179 |
0.732 |
0.089 |
0.000 |
0.000 |
0.179 |
0.036 |
0.000 |
|
Kashmiri |
24 |
32.44 |
0.000 |
0.320 |
0.480 |
0.080 |
0.480 |
0.420 |
0.000 |
0.180 |
0.800 |
0.020 |
0.000 |
0.000 |
0.160 |
0.020 |
0.000 |
|
Konkani |
43 |
15.00 |
0.000 |
0.115 |
0.192 |
0.346 |
0.308 |
0.288 |
0.000 |
0.080 |
0.860 |
0.060 |
0.000 |
0.000 |
0.096 |
0.058 |
0.000 |
|
Malayalam |
25 |
10.00 |
0.000 |
0.130 |
0.222 |
0.333 |
0.426 |
0.315 |
0.000 |
0.148 |
0.759 |
0.093 |
0.000 |
0.000 |
0.148 |
0.000 |
0.000 |
|
Marathi |
26 |
20.00 |
0.000 |
0.278 |
0.315 |
0.481 |
0.333 |
0.259 |
0.000 |
0.111 |
0.778 |
0.111 |
0.000 |
0.000 |
0.111 |
0.000 |
0.000 |
|
Marwari |
25 |
27.00 |
0.006 |
0.265 |
0.243 |
0.265 |
0.423 |
0.296 |
0.008 |
0.186 |
0.758 |
0.044 |
0.000 |
0.003 |
0.193 |
0.019 |
0.003 |
|
Oriya |
27 |
20.00 |
0.019 |
0.192 |
0.231 |
0.250 |
0.308 |
0.346 |
0.000 |
0.231 |
0.692 |
0.077 |
0.000 |
0.000 |
0.231 |
0.000 |
0.000 |
|
Parsi |
25 |
19.00 |
0.020 |
0.280 |
0.180 |
0.240 |
0.320 |
0.440 |
0.000 |
0.240 |
0.660 |
0.100 |
0.000 |
0.000 |
0.240 |
0.020 |
0.000 |
|
Punjabi |
28 |
30.40 |
0.017 |
0.155 |
0.241 |
0.259 |
0.379 |
0.345 |
0.034 |
0.259 |
0.690 |
0.017 |
0.000 |
0.000 |
0.241 |
0.000 |
0.017 |
|
Tamil |
29 |
11.00 |
0.018 |
0.161 |
0.321 |
0.143 |
0.429 |
0.393 |
0.018 |
0.232 |
0.714 |
0.036 |
0.000 |
0.000 |
0.232 |
0.054 |
0.018 |
|
Telugu |
28 |
16.00 |
0.000 |
0.229 |
0.271 |
0.167 |
0.354 |
0.229 |
0.000 |
0.229 |
0.688 |
0.063 |
0.021 |
0.000 |
0.229 |
0.000 |
0.000 |
|
FST |
0.016 |
0.008 |
0.002 |
0 |
0.011 |
0.010 |
0.006 |
0.013 |
0.009 |
0.013 |
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|
p-value |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
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|
|
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|
Gender |
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|
Female |
237 |
0.002 |
0.241 |
0.241 |
0.295 |
0.390 |
0.316 |
0.008 |
0.191 |
0.733 |
0.066 |
0.002 |
0 |
0.192 |
0.017 |
0.006 |
|
|
Male |
339 |
0.013 |
0.224 |
0.254 |
0.236 |
0.385 |
0.320 |
0.004 |
0.192 |
0.753 |
0.049 |
0 |
0.001 |
0.193 |
0.016 |
0.003 |
|
|
FST |
0 |
0.041 |
0.046 |
0 |
0.052 |
0.052 |
0 |
0.052 |
0.052 |
0.037 |
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|
p-value |
1 |
0.839 |
0.830 |
1 |
0.820 |
0.820 |
1 |
0.819 |
0.820 |
0.847 |
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|
|
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|
Population |
|||||||||||||||||
|
Cohort |
576 |
0.009 |
0.231 |
0.248 |
0.260 |
0.387 |
0.319 |
0.006 |
0.192 |
0.745 |
0.056 |
0.001 |
0.001 |
0.193 |
0.016 |
0.004 |
|
|
Standard Error |
0.002 |
0.016 |
0.021 |
0.025 |
0.017 |
0.017 |
0.003 |
0.014 |
0.015 |
0.007 |
0.001 |
1.85 × 10-4 |
0.013 |
0.005 |
0.002 |
||
|
HWE Constant |
4.98 × 10-5 |
0.003 |
0.001 |
0.013 |
0.004 |
0.001 |
0.009 |
0.016 |
2.50 × 10-4 |
1.94 × 10-5 |
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|
p-value |
1 |
0.720 |
1 |
0.100 |
0.658 |
1 |
0.213 |
0.014 |
1 |
1 |
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|
Welch modified t-test: |
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|
Africa |
5.57 × 10-9 |
8.44 × 10-3 |
4.55 × 10-10 |
0.151 |
0.172 |
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|
Europe |
7.16 × 10-6 |
0.003 |
0.790 |
3.19 × 10-4 |
1.57 × 10-4 |
0.036 |
0.724 |
0.067 |
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|
Middle East |
1.94 × 10-9 |
0.007 |
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|
Central/South Asia |
0.006 |
4.65 × 10-5 |
1.16 × 10-6 |
4.89 × 10-14 |
0.432 |
1.37 × 10-7 |
0.007 |
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|
East Asia |
4.64 × 10-10 |
1.19 × 10-9 |
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|
Americas |
0.029 |
1.18 × 10-5 |
1.56 × 10-5 |
0.136 |
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|
Oceania |
1.17 × 10-8 |
0.002 |
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|
|
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|
P-values significant at <0.05 are shown in bold. °N = degrees of latitude north of the equator. |
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|
Pemberton et al. BMC Genetics 2008 9:13 doi:10.1186/1471-2156-9-13 |
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