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List of genes included in the study, with sequence screened and SNP frequency |
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| Gene |
Gene symbol |
Gene product category/function* |
Bp screened |
SNP/bp |
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| Dopamine related genes |
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| Tyrosine hydroxylase |
TH |
Presynaptic form. of DOPA |
1488 |
1/1488 |
| Dopamine transporter |
SLC6A3 |
Synaptic clearance of Dopamine |
1881 |
1/470 |
| Dopamine receptor D1 |
DRD1 |
G protein-coupled receptor |
1341 |
1/335 |
| Dopamine receptor D2 |
DRD2 |
G protein-coupled receptor |
1332 |
1/666 |
| Dopamine receptor D3 |
DRD3 |
G protein-coupled receptor |
1344 |
1/336 |
| Norepinephrine related gene |
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| Dopamine beta hydroxylase |
DBH |
Presynaptic form. of norepinephrine |
1839 |
1/306 |
| Serotonin related genes |
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| 5-hydroxytryptamine receptor 1A |
HTR1A |
G protein-coupled receptor |
1272 |
1/1272 |
| 5-hydroxytryptamine receptor 1B |
HTR1B |
G protein-coupled receptor |
1170 |
1/585 |
| 5-hydroxytryptamine receptor 1D |
HTR1D |
G protein-coupled receptor |
1134 |
1/283 |
| 5-hydroxytryptamine receptor 1E |
HTR1E |
G protein-coupled receptor |
1098 |
1/1098 |
| 5-hydroxytryptamine receptor 1F |
HTR1F |
G protein-coupled receptor |
1101 |
1/1101 |
| 5-hydroxytryptamine receptor 2A |
HTR2A |
G protein-coupled receptor |
1414 |
0 |
| 5-hydroxytryptamine receptor 2B |
HTR2B |
G protein-coupled receptor |
1305 |
1/652 |
| 5-hydroxytryptamine receptor 2C |
HTR2C |
G protein-coupled receptor |
1377 |
1/1377 |
| 5-hydroxytryptamine receptor 3A |
HTR3A |
Ligand-gated ion channel |
1452 |
1/1452 |
| 5-hydroxytryptamine receptor 4 |
HTR4 |
G protein-coupled receptor |
1167 |
0 |
| Serotonin transporter |
SLC6A4 |
Synaptic clearance of Serotonin |
1845 |
0 |
| Tryptophan hydroxylase 1 |
TPH1 |
Presynaptic form. of hydroxytryptophan (5HT) |
1335 |
0 |
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| Sum of bp screened |
24895 |
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| No. of SNPs detected |
34 |
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| Frequency of SNPs (snp/bp) |
1/732 |
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| Synonym (n = 23) |
1/1082 |
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| Non-synonym (n = 11) |
1/2263 |
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* As defined at [35] | ||||
Våge and Lingaas BMC Genetics 2008 9:10 doi:10.1186/1471-2156-9-10 |
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