BMC Genetics

official impact factor 2.49

Open Access Research article

An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study

Jun Wu1*, Michael A Province1, Hilary Coon2, Steven C Hunt3, John H Eckfeldt4, Donna K Arnett5, Gerardo Heiss6, Cora E Lewis7, R Curtis Ellison8, Dabeeru C Rao9, Treva Rice9 and Aldi T Kraja1

Author Affiliations

1 Division of Statistical Genomics, Washington University School of Medicine, Campus Box 8506, 4444 Forest Park Boulevard, Saint Louis, MO63108, USA

2 Department of Psychiatry, University of Utah, Salt Lake City, UT, USA

3 Cardiovascular Genetics, University of Utah, Salt Lake City, UT, USA

4 Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, USA

5 University of Alabama at Birmingham, Birmingham, AL, USA

6 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA

7 Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

8 Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA

9 Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA

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BMC Genetics 2007, 8:60 doi:10.1186/1471-2156-8-60

Published: 10 September 2007

Additional files

Additional file 1:

Appendix A and Appendix B. Appendix A includes Table A1 and A2 showing the detailed results from individual clinical trials for HMG-CoA Inhibitors and Fibric Acid Derivatives as mono-drug therapy, along with Figure A1-A4 for multipoint genome scan results of lipids in HyperGEN based on SEGPATH software. Appendix A may also be found on the following website: http://www.biostat.wustl.edu/hypergen/results.html webcite. Appendix B lists the citations for all clinical trials summarized in Table A1 and A2.

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