Table 1 |
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|
Differentially expressed genes in GAN vs. normal fibroblasts as analyzed by oligonucleotide microarrays. Genes selected displayed at least a three-fold difference in expression level. |
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|
Name |
Acc. number |
Fold change |
|
|
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|
Genes involved in lipid metabolism and adipogensis |
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|
Complement component 3 precursor |
NM_000064.1 |
33.67 |
|
Butyrylcholinesterase |
NM_000055 |
20.67 |
|
Alpha-2,8-sialyltransferase |
L32867.1 |
6.95 |
|
Fatty acid binding protein 5 |
NM_001444.1 |
6.48 |
|
ATP-binding cassette A6 |
AA099357 |
4.38 |
|
Meltrin alpha |
W46291 |
5.51 |
|
Adipsin |
NM_001928.1 |
-7.39 |
|
ATP-binding cassette B4 |
NM_000443.2 |
-9.77 |
|
Acyl coenzyme A:cholesterol acyltransferase |
S73751.1 |
-24.91 |
|
Leptin |
NM_000230.1 |
-34.35 |
|
Integral membrane proteins and receptors |
||
|
GABA-B receptor |
AF056085.1 |
8.85 |
|
Integrin, beta 3 |
M35999.1 |
4.89 |
|
GABA-B receptor R2 |
AF095784.1 |
5.05 |
|
GABA-B receptor splice variant 1 |
AF095723.1 |
6.06 |
|
Orphan G protein-coupled receptor |
AF069755.1 |
4.52 |
|
Integral membrane serine protease |
U76833.1 |
4.63 |
|
Hyaluronan-mediated motility receptor |
NM_012485.1 |
3.14 |
|
Death receptor 6 |
BE568134 |
-4.14 |
|
Endothelin receptor |
M74921.1 |
-5.12 |
|
P-glycoprotein (mdr1) |
AF016535.1 |
-7.95 |
|
Membrane glycoprotein M6 |
D49958.1 |
-5.82 |
|
C18ORF1 |
NM_004338.1 |
-4.19 |
|
Glycoprotein M6A |
BF939489 |
-6.68 |
|
Potassium channel beta subunit |
L39833.1 |
-5.44 |
|
Endothelin receptor type B |
NM_003991.1 |
-8.89 |
|
Potassium channel beta 1a subunit |
U33428.1 |
-3.99 |
|
E-cadherin |
NM_004360.1 |
-7.04 |
|
Cell division/proliferation/apoptosis |
||
|
Survivin |
NM_001168.1 |
6.37 |
|
PDZ-binding kinase |
NM_018492.1 |
4.38 |
|
Survivin-beta |
AB028869.1 |
6.53 |
|
Mitosin (CENPF) |
NM_005196.1 |
3.79 |
|
Dickkopf homolog 1 |
NM_012242.1 |
4.59 |
|
Kinetochore associated 2 |
NM_006101.1 |
3.51 |
|
Cell division cycle 2 |
AL524035 |
3.47 |
|
WNT4 |
NM_030761.1 |
-4.05 |
|
Fritz |
U91903.1 |
-4.83 |
|
Tumor necrosis factor-related protein |
NM_030945.1 |
-6.03 |
|
EGF-like-domain, multiple 6 |
NM_015507.2 |
-8.22 |
|
Transcription factors and nuclear proteins |
||
|
Transcription factor AP-2 alpha |
BF343007 |
7.41 |
|
High mobility group AT-hook 1 |
NM_002131.1 |
5.58 |
|
Nuclear factor IB |
AI700518 |
4.49 |
|
Interferon-inducible protein p78 |
NM_002462.2 |
7.57 |
|
Cytoskeleton |
||
|
Rabkinesin6 |
NM_005733.1 |
4.66 |
|
Stathmin-like 2 |
NM_007029.1 |
-5.32 |
|
Pregnancy specific beta-1-glycoprotein |
||
|
Pregnancy specific beta-1-glycoprotein 7 |
NM_002783.1 |
-5.85 |
|
Pregnancy specific beta-1-glycoprotein 4 |
NM_002780.1 |
-17.82 |
|
Pregnancy specific beta-1-glycoprotein 1 |
NM_006905.1 |
-62.90 |
|
Uncharacterized genes |
||
|
Hypothetical protein PRO02730 |
AL137654 |
10.56 |
|
Uncharacterized bone marrow protein |
NM_018454.1 |
5.06 |
|
Hypothetical protein FLJ10517 |
NM_018123.1 |
5.74 |
|
KIAA0101 gene product |
NM_014736.1 |
5.10 |
|
KIAA0008 gene product |
NM_014750.1 |
4.62 |
|
Doublecortin and CaM kinase-like 1 |
NM_004734.1 |
4.53 |
|
KIAA1547 gene product |
AW873621 |
3.96 |
|
Hypothetical protein DKFZp762E1312 |
NM_018410.1 |
4.54 |
|
Hypothetical protein FLJ10829 |
NM_018234.1 |
5.12 |
|
Clone HQ0310 PRO0310p1 |
NM_016359.1 |
4.38 |
|
Hypothetical protein DKFZp564H1916 |
AI186739 |
3.69 |
|
KIAA0042 gene product |
NM_014875.1 |
4.96 |
|
Hypothetical protein FLJ22009 |
NM_024745.1 |
4.11 |
|
Hypothetical protein FLJ23468 |
NM_024629.1 |
3.48 |
|
Hypothetical protein DKFZp564N1116 |
BF344237 |
4.03 |
|
Hypothetical protein FLJ10781 |
NM_018215.1 |
-3.68 |
|
Myomegalin |
AB042557.1 |
-4.97 |
|
Hypothetical protein DKFZp564B052 |
NM_030820.1 |
-5.46 |
|
KIAA0008 gene product |
AK002054.1 |
-16.44 |
|
MGC:3052 |
BC002449.1 |
-7.73 |
|
KIAA0865 gene product |
AI522028 |
-7.70 |
|
Miscellaneous |
||
|
Matrix metalloproteinase 1 |
NM_002421.2 |
7.73 |
|
Carbonic anhydrase XII |
NM_001218.2 |
7.80 |
|
Topoisomerase II alpha |
AU159942 |
6.87 |
|
Step II splicing factor SLU7 |
AV733266 |
6.93 |
|
Monocyte chemotactic protein |
S69738.1 |
4.37 |
|
Ribonucleotide reductase M2 |
BE966236 |
4.59 |
|
Plasminogen activator, urokinase |
NM_002658.1 |
4.19 |
|
Cathepsin C |
NM_001814.1 |
4.34 |
|
Atrophin-1 interacting protein 1 |
NM_012301.1 |
-3.89 |
|
Monoamine oxidase A |
AA923354 |
-4.77 |
|
Type II iodothyronine deiodinase |
U53506.1 |
-2.80 |
|
Phosphatidylserine-binding protein |
NM_004657.1 |
-3.98 |
|
Scrapie responsive protein 1 |
NM_007281.1 |
-5.72 |
|
Natural killer cell transcript 4 |
NM_004221.1 |
-5.94 |
|
CD24 signal transducer |
L33930 |
-9.16 |
|
Elastase 2 |
NM_001972.1 |
-9.71 |
|
CD24 antigen |
AA761181 |
-19.19 |
|
|
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|
Leung et al. BMC Genetics 2007 8:6 doi:10.1186/1471-2156-8-6 |
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