Table 1

Differentially expressed genes in GAN vs. normal fibroblasts as analyzed by oligonucleotide microarrays. Genes selected displayed at least a three-fold difference in expression level.

Name

Acc. number

Fold change


    Genes involved in lipid metabolism and adipogensis

Complement component 3 precursor

NM_000064.1

33.67

Butyrylcholinesterase

NM_000055

20.67

Alpha-2,8-sialyltransferase

L32867.1

6.95

Fatty acid binding protein 5

NM_001444.1

6.48

ATP-binding cassette A6

AA099357

4.38

Meltrin alpha

W46291

5.51

Adipsin

NM_001928.1

-7.39

ATP-binding cassette B4

NM_000443.2

-9.77

Acyl coenzyme A:cholesterol acyltransferase

S73751.1

-24.91

Leptin

NM_000230.1

-34.35

    Integral membrane proteins and receptors

GABA-B receptor

AF056085.1

8.85

Integrin, beta 3

M35999.1

4.89

GABA-B receptor R2

AF095784.1

5.05

GABA-B receptor splice variant 1

AF095723.1

6.06

Orphan G protein-coupled receptor

AF069755.1

4.52

Integral membrane serine protease

U76833.1

4.63

Hyaluronan-mediated motility receptor

NM_012485.1

3.14

Death receptor 6

BE568134

-4.14

Endothelin receptor

M74921.1

-5.12

P-glycoprotein (mdr1)

AF016535.1

-7.95

Membrane glycoprotein M6

D49958.1

-5.82

C18ORF1

NM_004338.1

-4.19

Glycoprotein M6A

BF939489

-6.68

Potassium channel beta subunit

L39833.1

-5.44

Endothelin receptor type B

NM_003991.1

-8.89

Potassium channel beta 1a subunit

U33428.1

-3.99

E-cadherin

NM_004360.1

-7.04

    Cell division/proliferation/apoptosis

Survivin

NM_001168.1

6.37

PDZ-binding kinase

NM_018492.1

4.38

Survivin-beta

AB028869.1

6.53

Mitosin (CENPF)

NM_005196.1

3.79

Dickkopf homolog 1

NM_012242.1

4.59

Kinetochore associated 2

NM_006101.1

3.51

Cell division cycle 2

AL524035

3.47

WNT4

NM_030761.1

-4.05

Fritz

U91903.1

-4.83

Tumor necrosis factor-related protein

NM_030945.1

-6.03

EGF-like-domain, multiple 6

NM_015507.2

-8.22

    Transcription factors and nuclear proteins

Transcription factor AP-2 alpha

BF343007

7.41

High mobility group AT-hook 1

NM_002131.1

5.58

Nuclear factor IB

AI700518

4.49

Interferon-inducible protein p78

NM_002462.2

7.57

    Cytoskeleton

Rabkinesin6

NM_005733.1

4.66

Stathmin-like 2

NM_007029.1

-5.32

    Pregnancy specific beta-1-glycoprotein

Pregnancy specific beta-1-glycoprotein 7

NM_002783.1

-5.85

Pregnancy specific beta-1-glycoprotein 4

NM_002780.1

-17.82

Pregnancy specific beta-1-glycoprotein 1

NM_006905.1

-62.90

    Uncharacterized genes

Hypothetical protein PRO02730

AL137654

10.56

Uncharacterized bone marrow protein

NM_018454.1

5.06

Hypothetical protein FLJ10517

NM_018123.1

5.74

KIAA0101 gene product

NM_014736.1

5.10

KIAA0008 gene product

NM_014750.1

4.62

Doublecortin and CaM kinase-like 1

NM_004734.1

4.53

KIAA1547 gene product

AW873621

3.96

Hypothetical protein DKFZp762E1312

NM_018410.1

4.54

Hypothetical protein FLJ10829

NM_018234.1

5.12

Clone HQ0310 PRO0310p1

NM_016359.1

4.38

Hypothetical protein DKFZp564H1916

AI186739

3.69

KIAA0042 gene product

NM_014875.1

4.96

Hypothetical protein FLJ22009

NM_024745.1

4.11

Hypothetical protein FLJ23468

NM_024629.1

3.48

Hypothetical protein DKFZp564N1116

BF344237

4.03

Hypothetical protein FLJ10781

NM_018215.1

-3.68

Myomegalin

AB042557.1

-4.97

Hypothetical protein DKFZp564B052

NM_030820.1

-5.46

KIAA0008 gene product

AK002054.1

-16.44

MGC:3052

BC002449.1

-7.73

KIAA0865 gene product

AI522028

-7.70

Miscellaneous

Matrix metalloproteinase 1

NM_002421.2

7.73

Carbonic anhydrase XII

NM_001218.2

7.80

Topoisomerase II alpha

AU159942

6.87

Step II splicing factor SLU7

AV733266

6.93

Monocyte chemotactic protein

S69738.1

4.37

Ribonucleotide reductase M2

BE966236

4.59

Plasminogen activator, urokinase

NM_002658.1

4.19

Cathepsin C

NM_001814.1

4.34

Atrophin-1 interacting protein 1

NM_012301.1

-3.89

Monoamine oxidase A

AA923354

-4.77

Type II iodothyronine deiodinase

U53506.1

-2.80

Phosphatidylserine-binding protein

NM_004657.1

-3.98

Scrapie responsive protein 1

NM_007281.1

-5.72

Natural killer cell transcript 4

NM_004221.1

-5.94

CD24 signal transducer

L33930

-9.16

Elastase 2

NM_001972.1

-9.71

CD24 antigen

AA761181

-19.19


Leung et al. BMC Genetics 2007 8:6   doi:10.1186/1471-2156-8-6

Open Data