Analysis of D2.Tyrp1B6GpnmbB6 mice. A. D2.Tyrp1B6GpnmbB6 mice (right) show a darker coat color compared to D2 mice (left) due to the presence of a wild-type Tyrp1 gene. B-C. Regions of B6-derived sequence containing Tyrp1 (B) and Gpnmb (C) are indicated by the black horizontal lines, dotted lines indicate the region within which the breakpoints lie. The estimated maximum sizes of the regions (taken from Ensembl) are indicated. Polymorphic markers flanking the breakpoint regions are shown and the orientation of the genes are indicated below.
Howell et al. BMC Genetics 2007 8:45 doi:10.1186/1471-2156-8-45