Additional file 4.

Alignment of DLX5 protein sequences in six vertebrates. a) The region corresponding to amino acid residues 219–244 in the human sequence is depicted. Sequences are listed by GenBank accession and species (HS, Homo sapiens; MM, Mus musculus; RN, Rattus norvegicus; GG, Gallus gallus; XL, Xenopus laevis; and DR, Danio rerio). Type color depicts alignment status (red on yellow, completely conserved; blue on cyan, consensus derived from block of similar residues; green, residue weakly similar to consensus residue; black, non-similar to consensus residue; black on green, consensus derived from majority residue). The location of the residue affected by DLX5 SNPs is shown by the arrows (SNP-6, Ser/Pro; SNP-7, Ser/Arg). b) Phlyogenetic tree for the entire DLX5 protein sequence of six vertebrates calculated using neighbor joining method (reference 51, Saitou and Nei, 1987). The distances in parentheses represent the degree of divergence between sequences.

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Hamilton et al. BMC Genetics 2005 6:52   doi:10.1186/1471-2156-6-52