|
Genotype frequency of two MLPH polymorphisms in different breeds |
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| Breed and phenotype |
No. of animals |
dilute genotype1 |
Exon 22 |
Exon 7 |
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|
|
|
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| CC3 |
CT |
TT |
199R199R |
199R199H |
199H199H |
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|
|
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| Doberman Pinscher (all) |
140 |
50 (36%) |
69 (49%) |
21 (15%) |
82 (59%) |
47 (34%) |
11 (8%) |
|
| wildtype coat color |
98 |
D. |
50 (51%) |
48 (49%) |
- |
62 (63%) |
33 (34%) |
3 (3%) |
| wildtype coat color |
21 |
Dd |
- |
21 (100%) |
- |
9 (43%) |
12 (57%) |
- |
| dilute coat color |
21 |
dd |
- |
- |
21 (100%) |
11 (52%) |
2 (10%) |
8 (38%) |
| Doberman Pinscher (American origin) |
38 |
6 (16%) |
21 (55%) |
11 (29%) |
35 (92%) |
3 (8%) |
- |
|
| wildtype coat color |
19 |
D. |
6 (32%) |
13 (68%) |
- |
16 (84%) |
3 (16%) |
- |
| wildtype coat color |
8 |
Dd |
- |
8 (100%) |
- |
8 (100%) |
- |
- |
| dilute coat color |
11 |
dd |
- |
- |
11 (100%) |
11 (100%) |
- |
- |
| Doberman Pinscher (European origin) |
102 |
44 (43%) |
48 (47%) |
10 (10%) |
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| wildtype coat color |
79 |
D. |
44 (56%) |
35 (44%) |
- |
46 (58%) |
30 (38%) |
3 (4%) |
| wildtype coat color |
13 |
Dd |
- |
13 (100%) |
- |
1 (8%) |
12 (92%) |
- |
| dilute coat color |
10 |
dd |
- |
- |
10 (100%) |
- |
2 (20%) |
8 (80%) |
| German Pinscher |
143 |
143 (100%) |
- |
- |
64 (45%) |
61 (43%) |
18 (13%) |
|
| wildtype coat color |
117 |
D. |
117 (100%) |
- |
- |
64 (55%) |
53 (45%) |
- |
| wildtype coat color |
8 |
Dd |
8 (100%) |
- |
- |
- |
8 (100%) |
- |
| dilute coat color |
18 |
dd |
18 (100%) |
- |
- |
- |
- |
18 (100%) |
| Beagle |
6 |
1 |
3 |
2 |
1 |
3 |
2 |
|
| wildtype coat color |
2 |
D. |
1 |
1 |
1 |
1 |
||
| wildtype coat color |
2 |
Dd |
2 |
2 |
||||
| dilute coat color |
2 |
dd |
2 |
2 |
||||
| Large Munsterlander |
12 |
- |
8 |
4 |
- |
7 |
5 |
|
| wildtype coat color |
8 |
Dd |
- |
8 |
- |
- |
7 |
1 |
| dilute coat color & BHFD |
4 |
dd |
- |
- |
4 |
- |
- |
4 |
| Weimeraner (dilute coat color) |
1 |
dd |
1 |
1 |
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| Am. Staffordshire (dilute col. & CDA) |
1 |
dd |
1 |
1 |
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| Mountain Dogs |
26 |
D. |
25 |
1 |
25 |
1 |
||
| Breeds unspecified |
12 |
D. |
10 |
2 |
9 |
3 |
||
| total |
341 |
229 (67%) |
85 (25%) |
27 (8%) |
181 (53%) |
124 (36%) |
36 (11%) |
|
|
1 A dog with wildtype coat color has the dilute genotype DD or Dd. If the animal has never produced any dilute (dd) offspring, the genotype can not be deduced unambiguously from the phenotype and the genotype is then denoted "D.". Among the Pinschers with wildtype coat colors there were also obligate carriers of the dilute allele (Dd), as these animals had dilute (dd) progeny. 2 This polymorphism corresponds to the silent C/T SNP in exon 2 at position 164258 in the reference sequence [EMBL:BN000728]. 3 The following associations were highly significant in Pinscher breeds under Fisher's Exact Test (p < 0.001): Exon 2 for all Doberman Pinschers, American Doberman Pinschers, and European Doberman Pinschers; exon 7 for European Doberman Pinschers and for German Pinschers. Non-Pinscher breeds were not evaluated statistically because of their small sample numbers. | ||||||||
Philipp et al. BMC Genetics 2005 6:34 doi:10.1186/1471-2156-6-34 |
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