Table 3 |
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|
Cost coefficients for different types of misclassification |
||||
|
K |
R* |
p |
Cθ |
Cφ |
|
|
||||
|
0.005 |
0.5 |
0.05 |
0.01 |
540.29 |
|
0.15 |
0.01 |
458.99 |
||
|
1 |
0.05 |
0.01 |
478.32 |
|
|
0.15 |
0.01 |
432.67 |
||
|
2 |
0.05 |
0.01 |
440.18 |
|
|
0.15 |
0.01 |
415.60 |
||
|
0.05 |
0.5 |
0.05 |
0.09 |
51.59 |
|
0.15 |
0.10 |
43.82 |
||
|
1 |
0.05 |
0.08 |
45.67 |
|
|
0.15 |
0.10 |
41.31 |
||
|
2 |
0.05 |
0.08 |
42.03 |
|
|
0.15 |
0.10 |
39.68 |
||
|
|
||||
|
The column heading for this table are as follows: K = prevalence; R* = ratio of controls to cases; p = SNP minor allele frequency in affected population; Cθ = Cost coefficient corresponding to misclassification parameter θ – this is a lower bound of the percent increase in sample size necessary to maintain constant asymptotic power for every 1% increase in θ Cφ = Cost coefficient corresponding to misclassification parameter φ – this is a lower bound of the percent increase in sample size necessary to maintain constant asymptotic power for every 1% increase in φ. The cost coefficients are computed using equation (1). |
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|
Edwards et al. BMC Genetics 2005 6:18 doi:10.1186/1471-2156-6-18 |
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