Table 1

Genetic models used for simulating case-control data.

Risk SNPs

Case Genotype Correlation

Allele

Marginal GRR

Penetrance Factors

Within System

Between System

Model

Number

Frequency

Het

Hom

0

1

2


H2M2

4

0.207

2.85

4.71

2.4E-02

0.51

1

0.30

-0.32

H4M2

8

0.160

1.99

2.96

3.9E-04

0.50

1

0.35

-0.12

H8M2

16

0.104

1.66

2.18

8.0E-06

0.56

1

0.32

-0.05

H16M2

32

0.069

1.46

1.78

1.4E-05

0.59

1

0.28

-0.02

H4M4

16

0.282

1.63

1.79

1.2E-08

0.79

1

0.17

-0.06

H8M4

32

0.214

1.34

1.40

2.8E-03

0.86

1

0.14

-0.02


Lunetta et al. BMC Genetics 2004 5:32   doi:10.1186/1471-2156-5-32

Open Data