Table 3

Indian-specific sub-clades of mtDNA haplogroups M and R.

DIAGNOSTIC CODING REGION MARKERS

ANCESTRAL HVS-I MOTIF

COALESCENCE (years)

ρ/nδ2 a

COALESCENCE b (years)

ρ/nδ2 a

nc

Proportion (95% CR)


M2

477G-1780-8502

16223–16319

70,600 ± 21,000

0.02

70,100 ± 20,700

0.04

166

6.1 (5.3–7.1)

M2a

5252–8369

16223-16319-16270

48,300 ± 20,100

0.03

46,700 ± 22,800

0.06

79

2.9 (2.3–3.6)

M2b

16223-16319-16274

54,800 ± 25,000

0.02

57,600 ± 22,300

0.06

87

3.2 (2.6–3.9)

M3a

4580

16126–16223

17,300 ± 7,400

0.10

17,300 ± 7,600

0.11

62

3.0f (2.4 – 3.8)

M4a

6620–7859

16223–16311

19,200 ± 9,000

0.23

19,100 ± 9,000

0.25

21

0.8 (0.5–1.2)

M6

3537

16223-16231-16362

33,000 ± 13,900

0.04

30,000 ± 13,600

0.08

79

2.9 (2.3–3.6)

M6a

16223-16231-16356-16362

19,100 ± 7,600

0.17

15,700 ± 8,100 d

0.54

37

1.4 (1.0–1.9)

M6b

5585

16188-16223-16231-16362

6,000 ± 2,100

0.73

12,100 ± 4,500

0,82

37

1.4 (1.0–1.9)

M18

16223-16318T

9,400 ± 3,200

0.31

17,100 ± 4,700

0.61

58

2.1 (1.7–2.7)

M25

15928

16223–16304

19,400 ± 7,200

0.30

22,300 ± 8,600

0.32

25

1.0g (0.7 – 1.5)

R2e

4216

16071

40,400 ± 14,300

0.45

52,500 ± 21,700

0.5

8

0.3 (0.2–0.6)

R5

8594

16266–16304

66,100 ± 22,000

0.04

69,800 ± 24,800

0.05

58

2.1 (1.7–2.7)

R6

-12282 AluI

16129–16362

30,000 ± 11,000

0.14

30,300 ± 11,600

0.19

35

1.3 (0.9–1.8)

Total

2719


a Efficiency of the sample for coalescence calculation (Saillard et al. 2000)

b Calculated without the tribal populations

c In the Indian subcontinent (a total of 2719 mtDNAs)

d Excluding also the scheduled cast of Mukri

e R2 is spread also in the Near East, Central Asia and Volga basin

f Excluding the datasets where M3* / M3a discrimination was impossible: 246 subjects from Andhra Pradesh (Bamshad et al. 1998); 382 Pushtoon, Koragas, Naga, Yerava, Pardhi, Paniya Adi, Andh, Apatani and Soligas (Cordaux et al. 2003); 35 Kota and Kurumba (Roychoudhury et al. 2001)

g Excluding the datasets where M* / M25 discrimination was impossible: 246 subjects from Andhra Pradesh (Bamshad et al. 1998); 39 Thoti and 29 subjects from Bangladesh (Cordaux et al. 2003); 12 Muria (Roychoudhury et al. 2001)

Metspalu et al. BMC Genetics 2004 5:26   doi:10.1186/1471-2156-5-26

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