Figure 2.

The products of swi gene A. The structure of the swi gene; exons are shown as boxes and introns as angled lines. Regions of exons encoding various domains are shaded: the histidine-rich domain (HR, black box), the threonine-rich domain (TR, grey box), the leucine-rich repeats (LRR, chess-desk box) and the cysteine-rich region (CR, shaded box). B. The alignment of the SWI amino acid sequence with amino acid sequences of its closest simalogs. For the better representation the following color code is applied. Residues in common between all proteins are marked in red, the ones common only between SWI, SWI2 and Dpse\SWI in pink and the ones identical only among the Dpse \SWI, SWI, and Agam\SWI2 are marked in black. Brown marks the amino acids common only between Dpse \SWI, Agam \SWI2 and SWI2 proteins, dark blue – the ones common only between SWI, Agam \SWI2 and SWI2. The pairs of amino acids identical between SWI and Dpse \SWI, SWI2 and Agam \SWI2, Agam \SWI2 and Dpse \SWI, Dpse \SWI and SWI2, SWI and Agam \SWI2 are marked in green, turquoise, violet, grey and blue, respectively. The amino acids similar between all four proteins are underlined. The CysXCys motives are boxed. Note the conserved Cys-379 (marked by a triangle) that is substituted in swit476 mutant flies. The regions of the proteins with the highest similarity to decorins are marked by dotted boxes.

Schwartz et al. BMC Genetics 2004 5:15   doi:10.1186/1471-2156-5-15
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