Optic nerve damage in AKXD28 mice. Representative nerve sections scored as (a) mild, (b) moderate, and (c) severe are shown. (d) Nerve damage is first evident in females. At 19 to 20 months all females are severely affected whereas approximately half of the males are. Original magnifications 630X.
Anderson et al. BMC Genetics 2001 2:1 doi:10.1186/1471-2156-2-1