Table 2

Genotype distributions, minor allele frequencies and unadjusted p-values for comparing genotype distribution according to diabetes status, additive allelic effects between diabetes groups
Non-diabetic Diabetic p-value Overall
N 575 212 787
IRS1
G/G, n (%) 526 (91.5) 199 (93.9) 0.485 725 (92.1)
G/A, n (%) 48 (8.3) 13 (6.1) 61 (7.7)
A/A, n (%) 1 (0.2) 0 (0) 1 (0.1))
A, n (%) 50 (4.4) 13 (3.1) 0.131 63 (4.0)
HWE (p-value) >0.999 >0.999 >0.999
PPARG
C/C, n (%) 521 (90.6) 183 (86.3) 0.161 704 (89.4)
C/G, n (%) 53 (9.2) 29 (13.7) 82 (10.4)
G/G, n (%) 1 (0.2) 0 (0) 1 (0.1)
G, n (%) 55 (4.9) 29 (6.8) 0.012 84 (5.3)
HWE (p-value) >0.999 0.605 0.719

HWE, Hardy-Weinberg Equilibrium (HWE p-values are from exact tests). IRS1, Insulin Substrate Receptor 1; PPARG, Peroxisome Proliferator-Activated Receptor Gamma.

Vergotine et al.

Vergotine et al. BMC Genetics 2014 15:10   doi:10.1186/1471-2156-15-10

Open Data