Table 1

General characteristics of the overall population and by diabetic status
Variable Non-diabetic Diabetic P-value Overall
Number 575 212 787
Gender, male n (%) 131 (22.8) 45 (21.2) 0.642 176
Mean age, year (SD) 51.3 (15.5) 59.3 (13.4) <0.0001 53.5 (15.4)
Mean systolic blood pressure, mmHg (SD) 123 (19) 131 (23) <0.0001 124 (21)
Mean diastolic blood pressure, mmHg (SD) 75 (12) 78 (15) 0.035 76 (13)
Hypertension, n (%) 306 (53.2) 138 (65.1) 0.003 444
Mean body mass index, kg/m2 (SD) 29.1 (7.1) 31.7 (7.2) <0.0001 29.8 (7.2)
Mean waist circumference, cm (SD) 95 (15) 102 (14) <0.0001 97 (16)
Mean hip circumference, cm (SD) 109 (14) 111 (15) 0.028 109 (14)
Mean waist/hip ratio, (SD) 0.87 (0.10) 0.92 (0.09) <0.0001 0.88 (0.10)
Mean HbA1c, % (SD) 5.7 (0.4) 7.8 (2.1) <0.0001 6.3 (1.5)
Mean HbA1c, mmol/mol (SD) 39 (4.4) 62 (23) <0.0001 45 (16.4)
Mean fasting blood glucose, mmol/l (SD) 5.1 (0.7) 9.8 (4.4) <0.0001 6.4 (3.1)
Mean 2 h glucose, mmol/l (SD) 6.4 (1.6) 13.4 (5.3) <0.0001 7.3 (3.5)
Mean eGFR, ml/min (SD) 76.0 (21.1) 71.2 (25.2) 0.015 74.7 (22.4)
Mean triglycerides, mmol/l (SD) 1.4 (0.9) 1.7 (0.9) <0.0001 1.5 (0.9)
Mean HDL cholesterol, mmol/l (SD) 1.3 (0.4) 1.2 (0.3) 0.0001 1.3 (0.4)
Mean LDL cholesterol, mmol/l (SD) 3.6 (1.0) 3.7 (1.1) 0.191 3.6 (1.0)
Mean total cholesterol, mmol/l (SD) 5.5 (1.2) 5.7 (1.3) 0.070 5.6 (1.2)
Median GGT (25th-75th percentiles) 26 [18-39] 31 [23-39] <0.0001 27 [19-42]
Median CRP (25th-75th percentiles) 3.4 [0.8-8.4] 5.2 [1.9-10.8] <0.0001 4.0 [1.1-9.4]
Median insulin mmol/l (25th-75th percentiles) 6.9 [3.3-12.5] 9.2 [3.7-16.6] 0.0009 7.5 [3.3-13.5]
Median 2 h insulin mmol/l (25th-75th percentiles) 35.3 [19.2-64.5] 58.9 [22.1-115.2] 0.0009 36.8 [19.5-72.7]
Median glucose/insulin (25th-75th percentiles) 0.72 [0.42-1.51] 0.88 [0.50-2.30] 0.016 0.75 [0.43-1.68]
Median HOMA-IR (25th-75th percentiles) 1.6 [0.7-2.9] 3.5 [1.5-6.7] <0.0001 1.9 [0.8-3.7]
Median HOMA-B% (25th-75th percentiles) 90.0 [41.1-160.0] 40.7 [12.4-77.8] <0.0001 71.2 [28.6-44.9]
Median QUICKI (25th-75th percentiles) 0.15 [0.14-0.18] 0.14 [0.13-0.15] <0.0001 0.15 [0.14-0.17]
Median FIRI (25th-75th percentiles) 1.4 [0.6-2.6] 3.1 [1.3-6.0] <0.0001 1.8 [0.7-3.3]
Median 1/HOMA-IR (25th-75th percentiles) 0.64 [0.34-1.49] 0.29 [0.15-0.66] <0.0001 0.54 [0.27-1.26]

CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; FIRI, fasting insulin resistance index; GGT, γ-glutamyltransferase; HbA1c, glycated haemoglobin; HDL, High Density Lipoproteins; HOMA-β%, functional β-cells; HOMA-IR, homeostatic model assessment of insulin resistance; LDL, Low Density Lipoproteins; QUICKI, the quantitative insulin-sensitivity check index; SD, standard deviation.

Vergotine et al.

Vergotine et al. BMC Genetics 2014 15:10   doi:10.1186/1471-2156-15-10

Open Data