Email updates

Keep up to date with the latest news and content from BMC Genetics and BioMed Central.

Open Access Research article

Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese

Yun Qian12*, Sijun Liu2, Feng Lu23, Huizhang Li24, Meihua Dong1, Yudi Lin1, Jiangbo Du2, Yuan Lin2, Jianhang Gong2, Guangfu Jin2, Juncheng Dai2, Zhibin Hu25 and Hongbing Shen25*

Author Affiliations

1 Department of Chronic Non-communicable Disease Control, Wuxi Center for Disease Control and Prevention, Wuxi, China

2 Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China

3 Department of Chronic Non-communicable Disease Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China

4 Department of Cancer Prevention and Treatment, Zhejiang Cancer Hospital, Hangzhou, China

5 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China

For all author emails, please log on.

BMC Genetics 2013, 14:86  doi:10.1186/1471-2156-14-86

Published: 22 September 2013

Abstract

Background

Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case–control study with 2,925 T2D patients and 3,281 controls in Han Chinese.

Results

Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19).

Conclusions

Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.

Keywords:
Fat mass and obesity-associated Gene; Genome-wide association study; Genetic susceptibility; Single nucleotide polymorphism; Type 2 diabetes