Table 2

False positive and true positive rates viaTotD|M, when v / μ is not known in advance
A. v/μ=0.
θμ σ=0(neutral) σ = − 10 σ = − 103/2 σ = − 102 σ = − 105/2
10-1 0.055 0.063 0.182 NA NA
10-1/2 0.059 0.052 0.162 0.333 NA
1(=100) 0.005 0.097 0.294 0.521 0.615
10+1/2 NAa 0.021 0.208 0.543 0.774
10+1 NA NA 0.008 0.488 0.699
B.v/μ=1.
θμ σ=0 (neutral) σ = − 10 σ = − 103/2 σ = − 102 σ = − 105/2
10-1 0.057 0.063 NA NA NA
10-1/2 0.038 0.175 0.203 0.625 NA
1(=100) 0.028 0.110 0.339 0.519 0.739
10+1/2 0.009 0.058 0.266 0.497 0.706
10+1 0.000 0.002 0.081 0.527 0.728
C.v/μ=3.
θμ σ=0 (neutral) σ = − 10 σ = − 103/2 σ = − 102 σ = − 105/2
10-1 0.051 0.000 NA NA NA
10-1/2 0.037 0.118 0.351 0.500 NA
1(=100) 0.037 0.140 0.240 0.528 0.815
10+1/2 0.050 0.131 0.293 0.547 0.746
10+1 0.078 0.142 0.293 0.585 0.734

NOTE. Here, n=100 and α = 1, as well as 5% nominal significance level, are fixed. The tables show proportions of loci that tested positive via TotD|M out of those whose gene genealogies revealed recurrent mutations. ν/μ is the backward/forward ratio of mutation rates. θμ(≡ 4) is the rescaled forward mutation rate. σ(≡ 4Ns) denotes the rescaled selection coefficient.

a “NA” is assigned to a category with less than 10 loci with revealed recurrent mutations.

Ezawa et al.

Ezawa et al. BMC Genetics 2013 14:37   doi:10.1186/1471-2156-14-37

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