Table 2

Correlation analyses, between ecological variables and CYP3A5 allelic and inferred expression data
Time period Ecological variable N=87 N=36
CYP3A5*3 CYP3A5*6 CYP3A5*7 High expresser allele (assuming CYP3A5*6 is a low/non-expresser allele) Low expresser allele (assuming CYP3A5*6 is a low/non-expresser allele) High expresser allele (assuming CYP3A5*6 is not a low/non-expresser allele) Low expresser allele (assuming CYP3A5*6 is not a low/non-expresser allele)
Rho P-value Rho P-value Rho P-value Rho P-value Rho P-value Rho P-value Rho P-value
Latitude 0.706 <0.0001 −0.331 0.048 −0.177 0.303 −0.472 0.004 0.472 0.004 −0.416 0.012 0.416 0.012
North latitude 0.666 <0.0001 −0.621 0.001 −0.410 0.047 −0.659 <0.0001 0.659 <0.0001 −0.620 0.001 0.620 0.001
South latitude 0.066 0.759 0.318 0.130 0.122 0.571 −0.701 <0.0001 0.701 <0.0001 −0.370 0.075 0.370 0.075
Temperature −0.664 <0.0001 0.268 0.114 0.494 0.002 0.655 <0.0001 −0.655 <0.0001 0.627 <0.0001 −0.627 <0.0001
Present Day Precipitation −0.129 0.232 −0.290 0.867 −0.150 0.384 −0.028 0.869 0.028 0.869 0.113 0.511 −0.113 0.511
Aridity 0.286 0.007 −0.201 0.24 −0.267 0.116 −0.185 0.279 0.185 0.279 −0.029 0.868 0.029 0.868
Temperature −0.597 <0.0001 0.216 0.207 0.342 0.041 0.560 0.0004 −0.560 0.0003 0.635 <0.0001 −0.635 <0.0001
Holocene Precipitation 0.072 0.510 −0.235 0.167 −0.522 0.001 −0.381 0.022 0.381 0.022 −0.190 0.266 0.190 0.266
Aridity 0.471 <0.0001 −0.344 0.04 −0.575 0.0002 −0.465 0.004 0.465 0.004 −0.293 0.083 0.293 0.0832
Temperature −0.644 <0.0001 0.297 0.079 0.608 <0.0001 0.649 <0.0001 −0.649 <0.0001 0.641 <0.0001 −0.641 <0.0001
Late Pleistocene Precipitation 0.160 0.139 −0.238 0.163 −0.353 0.035 −0.204 0.233 0.204 0.233 −0.023 0.892 0.023 0.892
Aridity 0.532 <0.0001 −0.436 0.008 −0.480 0.003 −0.379 0.026 0.379 0.023 −0.211 0.216 0.211 0.216

For analyses with inferred CYP3A5 expression phenotypes high-, intermediate- and low- expression diplotypes were counted as genotypes and the frequencies of expresser and low/non-expresser alleles calculated. For analyses with phenotypes, CYP3A5*6 was considered to cause low/non-expression and to have no effect on CYP3A5 expression. Significant p-values, at the 5% level, are shown in bold. Rho indicates Spearmann’s Rho. “N” refers to the number of populations analyzed for each CYP3A5 allele. For CYP3A5*3 frequencies, African data were combined with those previously reported [20]. For CYP3A5*6 and CYP3A5*7 correlations, only African data genotyped for this study were tested. North latitude and south latitude correlations were only performed with populations genotyped for this study.

Bains et al.

Bains et al. BMC Genetics 2013 14:34   doi:10.1186/1471-2156-14-34

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