Table 1

MiR-1 and miR-133 gene variants identified in familial AF probands
Gene Chromosome Nucleotide changea Major/Minor allele Minor allele frequencyb dbSNPc
AF Controls ESP 1000G
MIR1-1 20 −43C > T C/T 0.004 NA - - Novel
MIR1-2 18 +15A > G A/G 0.017 NA 0.020 0.018 rs9989532
+74T > C T/C 0.046 NA 0.087 0.071 rs78641532
MIR133A2 20 −102G > A G/A 0.142 0.122 - 0.207 rs45547937
−82G > A G/A 0.142 0.122 - 0.206 rs13040566
−19G > A G/A 0.142 0.122 0.229 0.207 rs13040413
79T > C T/C 0.004 0 - - Novel
+47T > C T/C 0.400 0.340 0.388 0.387 rs6062251
+69G > A G/A 0.004 0.010 0.006 0.009 rs149629841
MIR133B 6 −25delA A/- 0.083 NA 0.075 0.074 rs142410335

a Location of nucleotide changes is shown as (−) downstream or (+) upstream of the miRNA stem-loop sequence (as annotated by miRBase).

bAF, atrial fibrillation (n = 120, this study cohort); Controls, healthy volunteer subjects (n = 250, this study cohort); ESP, NHLBI Exome Sequencing Project (European American subgroup data); 1000G, 1000Genomes Project (European subgroup data). NA, data not available (not tested).

c dbSNP, Database of Single Nucleotide Polymorphisms [ http://www.ncbi.nlm.nih.gov/projects/SNP/ webcite].

Ohanian et al.

Ohanian et al. BMC Genetics 2013 14:18   doi:10.1186/1471-2156-14-18

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