Histological comparison of adrenal X-zone morphologies of DDD-Ay, DDD, B6-Ay, and B6 strains clearly indicating the differences between strains and between sexes. (A) Male adrenal cortex: X-zone was absent in the four strains. Localized atrophy of the cortex or irregularly arranged cortex cells was observed in DDD-Ay and DDD males, but not in B6-Ay and B6 males. (B) Female adrenal cortex: X-zone was present in the four strains. Infiltration of fat cells with large fat droplets was observed in the X-zones of strains DDD-Ay and DDD, whereas no marked changes were observed in strains B6-Ay and B6.
Suto BMC Genetics 2012 13:95 doi:10.1186/1471-2156-13-95