Table 2

Energy expenditure (heat production), respiratory exchange ratio (RER), locomotor activity (ambulatory count/day), and food intake of B6.TH-tabw2 congenic, subcongenic, and B6-homozygous control mice on chow and HFS diets over a 24 hour period (males)
Group Heat production (kcal/hour) RER Ambulatory count/day Food intake (kcal/day)
Chow
Control (n = 10) 0.4879 ± 0.0117ab 0.918 ± 0.007a 19766 ± 1668a n.d.
tabw2 (n = 4) 0.4880 ± 0.0185abc 0.916 ± 0.012a 15163 ± 2638ab n.d.
Line A (n = 10) 0.4691 ± 0.0117bc 0.907 ± 0.007a 18182 ± 1668ab n.d.
Line B (n = 8) 0.4479 ± 0.0131c 0.916 ± 0.008a 13994 ± 1865b n.d.
Line C (n = 9) 0.4556 ± 0.0123bc 0.923 ± 0.008a 19173 ± 1758a n.d.
Line D (n = 14) 0.5028 ± 0.0099a 0.925 ± 0.006a 18796 ± 1410a n.d.
ANOVA p-value 0.0081 0.5653 0.1850
HFS diets
Control (n = 12) 0.5541 ± 0.0107a 0.899 ± 0.007a 24571 ± 1523a 15.06 ± 0.52b
tabw2 (n = 3) 0.5713 ± 0.0214a 0.906 ± 0.014a 15962 ± 3046bc 18.99 ± 1.04a
Line A (n = 11) 0.5305 ± 0.0112a 0.866 ± 0.007b 14741 ± 1591c 12.87 ± 0.54c
Line B (n = 8) 0.5398 ± 0.0131a 0.909 ± 0.008a 16928 ± 1865bc 16.18 ± 0.63b
Line C (n = 18) 0.5377 ± 0.0087a 0.899 ± 0.006a 17188 ± 1243bc 15.61 ± 0.42b
Line D (n = 23) 0.5497 ± 0.0077a 0.890 ± 0.005a 19463 ± 1100b 15.20 ± 0.37b
ANOVA p-value 0.4033 0.0014 0.0004 <0.0001

Data are means ± SEM. Group means labeled with different letters are significantly different within a diet (P < 0.05).ND no data.

Stewart et al.

Stewart et al. BMC Genetics 2012 13:81   doi:10.1186/1471-2156-13-81

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