The woe2 eye phenotype at P28. Clinical evaluation of woe2 eyes identified microphthalmia with corneal opacities and neovascularization (B) when compared with WT mice (A). In about 25% of woe2 animals, unilateral or bilateral eyelid closure was noted (C). Histological analysis of woe2 eyes (E) identified anterior segment abnormalities with extensive anterior synechia (arrow), corneal hypertrophy (arrowhead) and stromal vascularization. Histological analysis of closed woe2 eyes (C) revealed aphakia with highly disorganized cornea, iris and retina (F). Histological analysis of adult woe2 eyelids (H) identified absence of meibomian glands (arrow) whereas meibomian glands were present in age-matched WT eyelids (G) (asterisk). Scale bar in D-H = 100 μm.
Toonen et al. BMC Genetics 2012 13:76 doi:10.1186/1471-2156-13-76