The Rabbit ortholog of mammalian CCL8 exist as a pseudogene. The “Orcu WGS” sequence shows parts of the exon embedding fragments of R-MCPgb region with outstanding similarity with mammalian MCP-2/CCL8 gene (Figure 4). The alignment with functional mammalian CCL8 clarifies the pseudogenization of Rabbit CCL8 gene. Exon regions are highlighted in gray, disabling mutations are highlighted in black. orcu: rabbit, hosa: human, susc: swine. The protein sequence shown is inferred from the susc_CCL8 sequence. Insertions were added at exon2 in order to maintain the reading frame. Open spaces are introduced at exon boundaries. ‘.’: identity with leader sequence, ‘-‘: deletions/insertions.
van der Loo et al. BMC Genetics 2012 13:72 doi:10.1186/1471-2156-13-72