Table 4

Power for all tests in simulated data of scenario D, no common SNPs effect, effects of RVs are in the different directions

OR

1.3

1.6

1.9

2.2

2.5

2.8

3.1


Rind

0.062

0.058

0.089

0.095

0.118

0.129

0.164


Rsum

0.054

0.062

0.092

0.083

0.113

0.118

0.158


Bind

0.062

0.06

0.059

0.074

0.085

0.1

0.128


Bsum

0.062

0.059

0.065

0.073

0.09

0.101

0.117


<a onClick="popup('http://www.biomedcentral.com/1471-2156/13/7/mathml/M78','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/7/mathml/M78">View MathML</a>

0.09

0.15

0.214

0.221

0.314

0.352

0.395


<a onClick="popup('http://www.biomedcentral.com/1471-2156/13/7/mathml/M79','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/7/mathml/M79">View MathML</a>

0.094

0.151

0.202

0.21

0.335

0.353

0.449


BwSum

0.107

0.096

0.096

0.136

0.179

0.221

0.27


BwOR

0.09

0.126

0.133

0.165

0.211

0.222

0.255


BKML

0.061

0.055

0.054

0.054

0.067

0.067

0.072


BSSU

0.056

0.053

0.052

0.05

0.062

0.062

0.068


BSSUw

0.095

0.126

0.181

0.254

0.314

0.354

0.478


BaSSU

0.086

0.087

0.13

0.138

0.167

0.162

0.229


BaSSUw

0.114

0.145

0.198

0.271

0.311

0.373

0.456


BaSSUOrd

0.113

0.175

0.241

0.289

0.39

0.409

0.566


BaSSUwOrd

0.129

0.2

0.256

0.321

0.385

0.468

0.543


BwSC

0.135

0.148

0.2

0.227

0.297

0.373

0.465


BwSCd

0.134

0.197

0.25

0.34

0.391

0.441

0.558


There is a customized LD structure among common variants and among rare variants.

Randomly selected eight rare variants are causal variants. Others are non-causal variants. Genetic effect parameters OR for eight rare variants are listed in the table. Odds Ratios for another half of rare variants are in different directions. If OR is 2, <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/7/mathml/M80','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/7/mathml/M80">View MathML</a> for eight casual rare variants. Notations of tests are defined similarly as those in Table 1.

Dai et al. BMC Genetics 2012 13:7   doi:10.1186/1471-2156-13-7

Open Data