Table 3

Power for all tests in simulated data of scenario C weak common SNPs effect, effects of RVs are in the same direction

OR

1.3

1.6

1.9

2.2

2.5

2.8

3.1


Rind

0.237

0.394

0.472

0.6

0.715

0.785

0.843


Rsum

0.247

0.418

0.543

0.636

0.747

0.811

0.869


Cbon

0.163

0.157

0.144

0.164

0.174

0.191

0.193


Clogit

0.195

0.199

0.193

0.207

0.212

0.228

0.238


Bind

0.278

0.364

0.436

0.517

0.618

0.677

0.76


Bsum

0.298

0.384

0.461

0.562

0.668

0.735

0.795


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0.236

0.43

0.565

0.702

0.781

0.888

0.91


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0.238

0.446

0.605

0.705

0.815

0.892

0.92


BwSum

0.341

0.534

0.658

0.703

0.846

0.87

0.911


BwOR

0.253

0.312

0.344

0.475

0.456

0.582

0.648


BKML

0.167

0.186

0.186

0.19

0.204

0.199

0.2


BSSU

0.165

0.179

0.179

0.181

0.192

0.192

0.188


BSSUw

0.203

0.334

0.458

0.61

0.716

0.808

0.861


BaSSU

0.168

0.215

0.235

0.28

0.303

0.34

0.383


BaSSUw

0.181

0.346

0.399

0.546

0.64

0.755

0.819


BaSSUOrd

0.163

0.293

0.376

0.571

0.592

0.733

0.798


BaSSUwOrd

0.238

0.367

0.506

0.663

0.732

0.847

0.89


BwSCd

0.21

0.395

0.484

0.625

0.661

0.822

0.848


BwSC

0.344

0.538

0.631

0.778

0.85

0.935

0.954


There is customized LD structure among common variants and among rare variants.

The OR for underlying common SNP is 1.5. Genetic effect parameter OR for eight rare variants is listed in the table. If OR is 2, Odds Ratio = (2, 2, 2, 2, 3, 3, 3, 3) for eight casual rare variants. Notations of tests are defined similarly as those in Table 1.

Dai et al. BMC Genetics 2012 13:7   doi:10.1186/1471-2156-13-7

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