Table 2

Power for all tests in simulated data of scenario B, no common SNPs effect, effects of RVs are in the same directions

OR

1.3

1.6

1.9

2.2

2.5

2.8

3.1

R_ind

0.227

0.376

0.522

0.63

0.737

0.81

0.851

R_sum

0.245

0.424

0.57

0.67

0.778

0.846

0.888

B_ind

0.129

0.204

0.318

0.419

0.522

0.623

0.698

B_sum

0.147

0.243

0.343

0.47

0.565

0.674

0.751

0.295

0.42

0.589

0.726

0.834

0.884

0.954

0.298

0.425

0.588

0.731

0.834

0.894

0.946

B_wSum

0.302

0.474

0.631

0.71

0.81

0.875

0.931

B_wOR

0.09

0.17

0.226

0.295

0.416

0.408

0.58

B_KML

0.044

0.054

0.057

0.067

0.08

0.074

0.078

B_SSU

0.042

0.049

0.053

0.062

0.075

0.071

0.07

B_SSUw

0.136

0.257

0.386

0.592

0.706

0.814

0.866

B_aSSU

0.074

0.106

0.197

0.219

0.275

0.324

0.351

B_aSSUw

0.161

0.243

0.378

0.504

0.691

0.755

0.823

B_aSSUOrd

0.234

0.325

0.468

0.628

0.738

0.849

0.877

B_aSSUwOrd

0.211

0.293

0.462

0.629

0.793

0.847

0.896

B_wSCd

0.201

0.34

0.445

0.586

0.734

0.825

0.885

B_wSC

0.316

0.509

0.654

0.775

0.892

0.927

0.97

There is a customized LD structure among common variants and among rare variants.

Randomly selected eight rare variants are casual variants. Others are non- casual variants. Genetic effect parameter OR for eight rare variants is listed in the table. If OR is 2, Odds Ratio = (2, 2, 2,3, 3, 3) for eight casual rare variants. Notations of tests are defined similarly those in Table 1.

Dai et al. BMC Genetics 2012 13:7   doi:10.1186/1471-2156-13-7