Table 2

Power for all tests in simulated data of scenario B, no common SNPs effect, effects of RVs are in the same directions

OR

1.3

1.6

1.9

2.2

2.5

2.8

3.1


Rind

0.227

0.376

0.522

0.63

0.737

0.81

0.851


Rsum

0.245

0.424

0.57

0.67

0.778

0.846

0.888


Bind

0.129

0.204

0.318

0.419

0.522

0.623

0.698


Bsum

0.147

0.243

0.343

0.47

0.565

0.674

0.751


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0.295

0.42

0.589

0.726

0.834

0.884

0.954


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0.298

0.425

0.588

0.731

0.834

0.894

0.946


BwSum

0.302

0.474

0.631

0.71

0.81

0.875

0.931


BwOR

0.09

0.17

0.226

0.295

0.416

0.408

0.58


BKML

0.044

0.054

0.057

0.067

0.08

0.074

0.078


BSSU

0.042

0.049

0.053

0.062

0.075

0.071

0.07


BSSUw

0.136

0.257

0.386

0.592

0.706

0.814

0.866


BaSSU

0.074

0.106

0.197

0.219

0.275

0.324

0.351


BaSSUw

0.161

0.243

0.378

0.504

0.691

0.755

0.823


BaSSUOrd

0.234

0.325

0.468

0.628

0.738

0.849

0.877


BaSSUwOrd

0.211

0.293

0.462

0.629

0.793

0.847

0.896


BwSCd

0.201

0.34

0.445

0.586

0.734

0.825

0.885


BwSC

0.316

0.509

0.654

0.775

0.892

0.927

0.97


There is a customized LD structure among common variants and among rare variants.

Randomly selected eight rare variants are casual variants. Others are non- casual variants. Genetic effect parameter OR for eight rare variants is listed in the table. If OR is 2, Odds Ratio = (2, 2, 2,3, 3, 3) for eight casual rare variants. Notations of tests are defined similarly those in Table 1.

Dai et al. BMC Genetics 2012 13:7   doi:10.1186/1471-2156-13-7

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