Table 6

Estimates of QTL position and main effect on PC1 and ADJPC1 of BM data
MIM MTMIM (GEM-NR) MTMIM (ECM)
PC1 ADJPC1 (PC1 and ADJPC1) (PC1 and ADJPC1)
QTL <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M6">View MathML</a>a <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M7','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M7">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M8','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M8">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M9','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M9">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M10','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M10">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M11','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M11">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M12','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M12">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M13','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M13">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M14','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M14">View MathML</a>
Chromosome X
1 1 0.0020 1 0.0165 1 0.0021 0.0175 0.0021 0.0175
2 20 0.0018 20 0.0284 20 0.0017 0.0275 0.0017 0.0275
Chromosome 2
3 1 0.0304 1 0.0007 0.0293 0.0007 0.0293
4 14 0.0018 17 0.0215 17 0.0018 0.0220 0.0018 0.0220
5 26 0.0017 30 0.0141 29 0.0012 0.0146 0.0011 0.0146
6 71 0.0016 70 0.0017 -0.0048ns 0.0017 -0.0048ns
7 111 0.0009 116 0.0147 116 0.0011 0.0176 0.0011 0.0177
8 144 0.0012 144 0.0091 144 0.0011 0.0082 0.0011 0.0082
Chromosome 3
9 5 0.0013 4 0.0011 0.0107 0.0011 0.0107
10 17 0.0022 16 0.0503 17 0.0022 0.0427 0.0022 0.0426
11 48 0.0033 44 0.0279 45 0.0027 0.0253 0.0027 0.0254
12 54 0.0235 54 0.0007ns 0.0255 0.0007 0.0254
13 82 0.0033 83 0.0391 83 0.0034 0.0394 0.0034 0.0394
14 112 0.0009 116 0.0324 115 0.0009 0.0257 0.0009 0.0257
15 129 0.0015 128 0.0012 0.0094ns 0.0012 0.0094ns
16 147 0.0007 146 0.0116 145 0.0009 0.0092 0.0009 0.0092
17 169 0.0021 166 0.0268 167 0.0021 0.0273 0.0021 0.0273
Total QTL 15 14 17
<a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M15','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M15">View MathML</a> 2.761 31.73
31.73 521.6
<a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M16','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M16">View MathML</a> 2.358 2.369 31.48
453.0 31.48 453.2

Estimates of QTL position ( <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M1','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M1">View MathML</a>) and main effect on PC1 ( <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M2','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M2">View MathML</a>) and ADJPC1 ( <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M3','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M3">View MathML</a>) in the MIM and MTMIM models of BM data with 10% genome-wide significance level. QTL effects in the MTMIM model were estimated via GEM-NR and ECM algorithms. Estimated phenotypic ( <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M4','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M4">View MathML</a>) and genotypic ( <a onClick="popup('http://www.biomedcentral.com/1471-2156/13/67/mathml/M5','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/13/67/mathml/M5">View MathML</a>) variance-covariance matrices (multiplied by 105 ) are also shown.

a Estimated position (cM) of QTL from the leftmost genetic marker on the chromosome.

ns Nonsignificant main effect tested with the LRT and 5% significance level. The critical value of the LRT was obtained from the chi-squared distribution function with one degree of freedom.

Costa E Silva et al.

Costa E Silva et al. BMC Genetics 2012 13:67   doi:10.1186/1471-2156-13-67

Open Data