Table 3

Results of the multi-allelic association of the KCNJ11 amino acid gene alleles with T2D.

Haplotype

Frequency


Common

Variations*

Control

Case

Coef

SE

OR

95% CI

Z-score

p-value


KCNJ11*aa*5

EVLIS

0.647

0.616

1

KCNJ11*aa*8

KVLVS

0.336

0.365

0.13

0.04

1.14

(1.05,1.24)

2.99

0.003

KCNJ11*aa*9

KVVVS

0.015

0.018

0.21

0.16

1.24

(0.9, 1.69)

1.32

0.188

Uncommon

KCNJ11*aa*4

EVLIT

0.001

0.0003

KCNJ11*aa*1

ELLIS

0.0005

0


By converting the predicted genomic gene allele to amino acid sequences, the total number of gene alleles is reduced to 5, with four amino acid variations (E23K, L64V, L270V, I337V, and S385C). The 3 common haplotypes were considered in this case-control study.

*The amino acid variations among the three common haplotypes are highlighted in bold.

Zhang et al. BMC Genetics 2012 13:6   doi:10.1186/1471-2156-13-6

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