Table 2

Results of the multi-allelic association of the KCNJ11 gene alleles with T2D.

Haplotype

Frequency


Common

Variations*

Control

Case

Coef

SE

OR

95% CI

Z-score

p-value


KCNJ11*3

GCCGGGGCT

0.336

0.364

1

KCNJ11*2

GCTGGGGCC

0.320

0.309

-0.11

0.05

0.9

(0.81,0.99)

-2.09

0.036

KCNJ11*1

GCTGGGACC

0.317

0.301

-0.12

0.05

0.89

(0.8, 0.98)

-2.29

0.022

KCNJ11*5

GCCGCGGCT

0.015

0.018

0.1

0.16

1.1

(0.8, 1.52)

0.59

0.558

Uncommon

KCNJ11*8

GTTGGGGCC

0.008

0.006

KCNJ11*4

GCTGGCGCC

0.0014

0.0005

KCNJ11*6

GCCTGGGCT

0.00078

0.001

KCNJ11*7

CCTGGGGCC

0.001

0.0003

KCNJ11*13

GCTGGGGAC

0.0005

0


In WTCCC1 cohort, which have 1924 T2D cases and 2938 controls (NBS and 58BC), a total of 9 gene alleles were predicted with variations at 9 SNP locations (rs41282930, rs8175351, rs5215, rs1800854, rs1800467, rs5216, rs5218, rs0#, rs5219). The 4 common gene alleles (freq > 0.01) were analyzed in a multi-allelic association in this case-control study.

*The SNP variations among the common haplotypes (freq > 0.01) are highlighted in bold.

#This SNP is located at chr11:17366025 (NCBI build 36) and has not been assigned an rs number.

Zhang et al. BMC Genetics 2012 13:6   doi:10.1186/1471-2156-13-6

Open Data