Table 4

QTL influencing hearing in CBA-F2 and C57-F2 mice
Line Trait Chr Marker LRS (LOD) pValue Effect
C57-F2
32 kHz ABR 10 rs13480621 280.2 (60.7) <0.00001 57%
HFEA 10 rs13480621 311.6 (67.6) <0.00001 63%
7 D7MIT83 10.2 (2.2) 0.00614 2%
PC1 10 rs13480621 259.9 (56.4) <0.00001 56%
PC2 10 rs13480621 25.8 (5.6) <0.00001 8%
PC3 10 rs39365220 12.0 (2.6) 0.00250 4%
5–9 kHz 10 rs3089912 19.2 (4.2) 0.00007 6%
10–14 kHz 10 rs13480621 20.4 (4.4) 0.00004 6%
15–19 kHz 10 rs13480621 35.3 (7.7) <0.00001 11%
20–24 kHz 10 rs13480621 143.0 (31.0) <0.00001 36%
25–29 kHz 10 rs13480621 202.6 (43.9) <0.00001 47%
30–34 kHz 10 rs13480621 250.1 (54.3) <0.00001 55%
35–39 kHz 10 rs13480621 290.1 (62.9) <0.00001 60%
7 D7MIT83 11.4 (2.5) 0.00336 2%
40–44 kHz 10 rs13480621 176.2 (38.2) <0.00001 43%
45–49 kHz 10 rs13480621 178.1 (38.6) <0.00001 22%
50–55 kHz 10 rs13480621 87.8 (19.0) <0.00001 24%
CBA-F2
HFEA 7 rs3680765 19.7 (4.27) 0.00005 7%
9 rs13480313 10.9 (2.4) 0.00425 4%
PC1 7 rs3680765 18.5 (4.0) 0.00010 6%
PC3 7 rs3719301 10.9 (2.4) 0.00428 4%
35–39 kHz 7 rs3680765 22.4 (4.9) 0.00001 7%
40–44 kHz 7 rs3680765 13.4 (2.9) 0.00122 5%
9 rs13480313 11.0 (2.4) 0.00415 4%
45–49 kHz 7 rs3680765 15.1 (3.3) 0.00053 5%
50–55 kHz 7 rs8255275 11.4 (2.5) 0.00346 4%

Chr, chromosome; HFEA, High Frequency Emissions Average.

Keller and Noben-Trauth

Keller and Noben-Trauth BMC Genetics 2012 13:32   doi:10.1186/1471-2156-13-32

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