Table 2

Association of the SNP in intron 5 of the ACSL1 gene (c.481-233A>G) with variation in intramuscular fatty acid composition and fat content

Model without IMF as covariate

Model with IMF as covariate

Trait*

LRT

p-value

Effect allele A

SE

Effect allele G

SE

Var [%]**

LRT

p-value

Effect allele A

SE

Effect allele G

SE


Total FA [mg]*&

6.2

0.0130

3.70

0.07

3.88

0.07

3.8

0.0507

MUFA [mg]*&

5.9

0.0154

3.29

0.08

3.48

0.09

2.9

0.0874

n-3 FA [%]*#

9.7

0.0018a

0.16

0.05

0.01

0.06

11.4

5.8

0.0159

0.42

0.04

0.36

0.04

PUFA [%]*#

7.1

0.0079b

1.12

0.05

0.98

0.06

3.5

3.9

0.0477

n-3 LC PUFA [%]#

6.7

0.0099b

0.24

0.03

0.16

0.04

3.4

3.5

0.0628

C18:1trans-11 [mg]*&

10.5

0.0012a

1.31

0.10

1.63

0.12

6.5

8.1

0.0045a

0.86

0.09

1.07

0.10

C22:5n-3 [%]#

7.2

0.0071 b

0.16

0.02

0.11

0.03

3.6

5.9

0.0150

0.27

0.02

0.23

0.02

PUFA/SFA*

7.3

0.0069b

-0.79

0.06

-0.94

0.07

3.6

4.2

0.0407

P/S*

6.7

0.0099b

-1.02

0.05

-1.15

0.06

3.2

3.2

0.0758

LA/ALA*

4.9

0.0265

1.03

0.03

0.97

0.03

1.9

0.1720

IMF [%]

3.1

0.0776

1.11

0.18

1.42

0.21

1.7


*Trait data log-transformed, &absolute content of fatty acids (mg/100 g of skeletal muscle), #relative content of fatty acids (percentage of the respective fatty acid fraction relative to total fatty acid amount)

LTR: likelihood ratio test, p: significancy of allelic effects, Var: variance explained, SE: standard error, aq-value <0.05, bq-value <0.1, **% variance in the model calculated as the relative reduction of the residual variance due to including the SNP in the model [47].

Allelic effects of the ACSL1 SNP (c.481-233A>G) on different FA fractions: n-3 fatty acids (n-3 FA = C18:3n-3 + C18:4n-3 + C20:5n-3 + C22:5n-3 + C22:6n-3), poly-unsaturated fatty acids (PUFA = n-3 FA + n-6 FA [C18:2n-6 + C18:3n-6 + C20:2n-6 + C20:3n-6 + C20:4n-6 + C22:2n-6 + C22:4n-6]), n-3 long-chain PUFA (n-3 LC-PUFA = C20:3n-3 + C22:6n-3 + C22:5n-3 + C20:5n-3), total FA, mono-unsaturated fatty acids (MUFA), docosapentaenoic fatty acid (DPA, C22:5n-3), trans vaccenic acid (TVA, C18:1trans-11) and the ratios: PUFA/SFA (saturated fatty acids = C12:0 + C14:0 + C16:0 + C17:0 + C18:0 + C20:0 + C24:0), P/S (C18:2 n-6 + C18:3 n-3/C14:0 + C16:0 + C18:0), LA/ALA (C18:2 n-6/C18:3 n-3), and the intramuscular fat content (IMF).

Widmann et al. BMC Genetics 2011 12:96   doi:10.1186/1471-2156-12-96

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