Table 3

Genotype-phenotype association analysis for muscular subsystem gene polymorphisms and baseline aerobic power and changes after training in the CAREGENE study

Gene

Polymorphism

Allele

Frequency

VO2pre

p-value

VO2 change

p-value

VO2 change

p-value

N (%)

(ml/min) a

(ml/min) b

(%) b


AMPD1

C34T/rs17602729

CC

652 (71)

1711 ± 15

p = 0.40

396 ± 10

p = 0.11

24.8 ± 0.6

p = 0.04

CT + TT

263 (29)

1734 ± 23

367 ± 16

22.4 ± 0.99

CNTF

G-6A/rs1800169

GG

664 (73)

1724 ± 15

p = 0.43

369 ± 9

p = 0.001

23.1 ± 0.6

p = 0.002

GA

226 (25)

1701 ± 25

416 ± 16

25.1 ± 1.0

AA

21 (2)

1801 ± 81

519 ± 52

33.9 ± 3.3

GR

R23K/rs6190

GG

857 (94)

1715 ± 13

p = 0.08

383 ± 9

p = 0.02

23.8 ± 0.6

p = 0.04

GA + AA

55 (6)

1805 ± 50

464 ± 34*

28.5 ± 2.2*


AMPD1, Adenosine monophosphate deaminase; CNTF, Ciliary neurotrophic factor; GR, Glucocorticoid receptor

a. Mean ± SE, corrected for gender, age, height and weight;

b. Mean ± SE, corrected for gender, age, height, weight and baseline peakVO2

Thomaes et al. BMC Genetics 2011 12:84   doi:10.1186/1471-2156-12-84

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